Follow-up after the treatment of ovarian cancer – really without Ca 125?


Authors: P. Freitag
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha přednosta prof. MUDr. A. Martan, DrSc.
Published in: Čes. Gynek.2012, 77, č. 6 s. 540-542

Overview

Results of study MRC OV05 and EORTC/GCCG 55955 (Rustin et al.) have raised a considerable interest and controversy by questioning the early beginning of recurrent ovarian cancer treatment and the role of Ca 125 monitoring in the follow-up of ovarian cancer patients. Main pitfalls and limitations of this study are introduced in a survey. On their basis an author´s opinion on the continuing role of Ca 125 monitoring is expressed with a possible benefit for the subgroup of patients with a solitary or operable relaps or those with new treatment possibilities or with inclusion to new clinical studies.

Key words:
ovarian cancer, follow-up, Ca 125.


Sources

1. Bast, RC. Jun. Ca 125 and the detection of recurrent ovarian cancer : a reasonably accurate biomarker for a difficult disease. Cancer, 2010, 116(12), p. 2850–2853.

2. Bukowski, RM., Ozols, RF., Markman, M. The management of recurrent ovarian cancer. Semin Oncol, 2007, 34, p. S1–15.

3. Colombo, N., Van Gorp, T., Parma, G., et al. Ovarian cancer. Crit Rev Oncol Hematol, 2006, 60(2), p. 159–179.

4. Goldman, PA. Ca 125: Value or addiction? Cancer, 2010, 116(12), p. 2854–2855.

5. Chi, DS., McCaughty, K., Diaz, JP., et al. Guidelines and selection criteria for secondary cytoreductive surgery in patients with recurrent, platinum-sensitive epithelial ovarian carcinoma. Cancer, 2006, 106(9), p. 1933–1939.

6. Karam, AK., Karlan, BY. Ovarian cancer: the duplicity of Ca 125 measurement. Nat Rev Clin Oncol, 2010, 7(6), p. 335–339.

7. Pignata, S., Canella, L., Leopardo, D., et al. Follow-up with Ca 125 after primary therapy for advanced ovarian cancer: in favor of continuing to prescribe Ca 125 during follow-up. Ann Oncol, 2011, 22, Suppl. 8, p. 40–44.

8. Rettenmaier, NB., Rettenmaier, CR., Wojciechowski, T., et al. The utility and cost of routine follow-up procedures in the surveillance of ovarian and primary peritoneal carcinoma: a 16-year institutional review. Br J Cancer, 2010, 103(11), p. 1657–1662.

9. Rosen, DG., Wang, L., Atkinson, JN., et al. Potential markers that complement expression of Ca 125 in epithelial ovarian cancer. Gynecol Oncol, 2005, 99, p. 267–277.

10. Rustin, GJ., van der Burg, ME., Griffin, CL., et al. Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial. Lancet, 2010, 376(9747), p. 1155–1163.

11. Verheijen, RH., Cibula, D., Zola, P., et al. Cancer antigen 125: lost to follow-up?: a European society of gynaecological oncology consensus statement. Int J Gynecol Cancer, 2012, 22(1), p. 170–174.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 6

2012 Issue 6

Most read in this issue

This topic is also in:


Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account