Role of leptin in human reproduction (anorexia, bulimia)

Authors: L. Pilka 1;  D. Rumpík 1;  R. Pilka 2
Authors‘ workplace: Klinika Reprofit International, s. r. o., Brno, ředitel MUDr. M. Koudelka 1;  Klinika gynekologie a porodnictví, LF UP a FN UP, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. 2
Published in: Čes. Gynek.2012, 77, č. 6 s. 484-485


Leptin may act as the critical link between adipose tissue and the reproductive systém, indicating whather adequate energy reserves are presenting for normal reproductive functions. Future interventional studies involving leptin administration are excepted to further clarify this role of leptin and may provide new therapeutic options for the reproductive dysfunctions associated with states of relative leptin deficiency or resistence.

Key words:
leptin, reproduction, hypothalamic-pituitary-gonadal axis.


1. Ferdorcsák, P., et al. Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod, 2004, 19, p. 2523–2528.

2. Norré, J., et al. The management of eating disorders in a fertility clinic: clinical guidelines. J Psychosom Obstet Gynecol, 2001, 22, p. 77–81.

3. Pasquali, R. Obesity and androgens: facto and perspectives. Fertil Steril, 2006, 85, p. 1319–1339.

4. Triech RE., Revelle, R. Heigh and weight at menarche and hypothesis of menarche. Arch Dis Child, 1971, 46, p. 695–701.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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Czech Gynaecology

Issue 6

2012 Issue 6

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