Ultrasound imaging of normal fetal central nervous system at 8 to 12 weeks of gestation

Authors: J. Vojtěch;  L. Krofta;  I. Urbánková;  K. Dlouhá;  L. Haaková;  J. Feyereisl
Authors‘ workplace: Ústav pro péči o matku a dítě, Praha, ředitel doc. MUDr. J. Feyereisl, CSc.
Published in: Ceska Gynekol 2011; 76(6): 446-449
Category: Original Article


With ongoing evolution of advanced ultrasound diagnostic in prenatal care the trend is to detect potential fetal anomalies in the first trimester if possible. Complex knowledge of normal fetal anatomy, embryology and ultrasound anatomy is important to be able to identify subtle abnormalities. In this review we demonstrate the possibilities of ultrasound imaging of fetal brain at late first trimester and describe normal central nervous system development week by week. Original images are presented.

Key words:
central nervous system, first trimester, ultrasound diagnostic, normal fetal anatomy, embryology, ultrasound anatomy.


1. Blaas, H-GK., Eik-Nes, SH. Sonoembryology and early prenatal diagnosis of neural anomalies. Prenat Diagn, 2009.

2. Blaas, H-GK., Eik-Nes, SH. Ultrasound assessment of normal fetal brain development. In: Fetal and neonatal neurology and neurosurgery, 4th ed. Levine, M., Chervenak, F., Whittle, M. eds. London: Churchill Livingstone, 2008.

3. Nicolaides, KH., Azar, G., Byrne, D., et al. Fetal nuchal translucency: ultrasound screening for chromosomal defect in first trimester of pregnancy. Brit Med J, 1992.

4. O’Rahilly, R., Müler, F. The embryonic human brain. An atlas of developmental stages. Hoboken, NJ: John Wiley and Sons, 2006.

5. Pilu, G., Sandri, F., Perolo, A., et al. Sonography of fetal agenesis of the corpus callosum. Ultrasound Gynekol Obstet, 1993, 3, p. 318–329.

6. Schmidt, W., Kubli, F. Early diagnosis of severe congenital malformations by ultrasonography. J Perinat Med, 1982.

7. Timor-Tritsch, IE., Monteagudo, A. Normal Two-Dimensional neurosonography of the prenatal brain, In: Timor-Tritsch et al. Ultrasonography of the prenatal and neonatal brain. New York: McGraw-Hill, 2001, p. 14–89.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account