Non-steroidal anti-inflammatory drugs in pregnancy

Authors: P. Valha 1;  J. Zmrhal 2;  J. Feyereisl 1
Authors‘ workplace: Ústav pro péči o matku a dítě, Praha 1;  Nemocnice s poliklinikou, Mělník 2
Published in: Čes. Gynek.2010, 75, č. 1 s. 69-72


Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic (lowering an elevated body temperature and relieving pain without impairing consciousness) and, in higher doses, with anti-inflammatory effects (reducing inflammation). As inhibitors of cyclooxygenase NSAIDs given during pregnancy have the potential to cause adverse maternal and fetal effects. Maternal effects include prolongation of pregnancy and labour, whereas constriction of the ductus arteriosus, renal dysfunction and haemostatic abnormalities can occur in the fetus and neonate. As weak acids, NSAIDs are excreted in small amounts into human breast milk with little risk for adverse effects in the suckling infant.

Key words:
cyclooxygenase inhibitors, ductus arteriosus, lactation, pregnancy/labour.


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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