In vitro determination of verapamil hydrochloride tablet dissolution


Authors: A. Štambergová;  Z. Ulbrichová;  J. Šedivý;  T. Sechser
Authors‘ workplace: Pracoviště klinické farmakologie Institutu klinické a experimentální medicíny, Praha
Published in: Čes. slov. Farm., 1999; , 214-217
Category:

Overview

Three different products containing 240 mg of verapamil hydrochloride in a coated tablet withsustained release were compared using the blinded dissolution test. The amount of the activesubstance released from the tablet and its dynamics differed significantly with all three productsafter 3 hours of dissolution. With product C (Isoptin SR, a proprietary product manufactured byKnoll), 92,2 % of the active substance was released after seven hours. With generic products A andB, the amounts were higher and lower, respectively. The dynamics of release of the active substancewas linear only with the proprietary product. Irregular and non-linear rates of active substancerelease from the tablet may result in clinically suboptimal efficacy and safety of generic products.

Key words:
dissolution test – verapamil – sustained release – UV spectrophotometry

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Pharmacy Clinical pharmacology
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account