Advances in the Development of New Antituberculotics from the Group of Five-Membe-red Heterocyclic Substances Containing Various Heteroatoms

Authors: K. Waisser;  L. Drhová
Authors‘ workplace: Katedra anorganické a organické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
Published in: Čes. slov. Farm., 1999; , 195-203


Tuberculosis and other antimycobacterial diseases are considered to be one of the most importantproblems of the health service at present. Since 1985, and in particular in the 1990s, a search fornew structures of antimycobacterial substances has ranked among the prior fields of chemothera-peutic research. The present review paper links up with the previous communications, and surveysthe studies carried out in the field of five-membered heterocyclic compounds containing moreheteroatoms since 1984. The most frequently investigated field is thiazole derivatives but the mostsuccessful papers originated in the group of oxazoles, where effective antituberculotics for clinicaluse can be expected in the future. The present research is based on the journal Chemical Abstractsand original papers.

Key words:
tuberculostatics –five-membered heterocycles – mycobacteria – antituberculotics

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Pharmacy Clinical pharmacology
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