Myasthenia Gravis Composite – Validation of the Czech Version

Authors: M. Chmelíková;  S. Voháňka;  J. Bednařík
Authors‘ workplace: Neurologická klinika LF MU a FN Brno
Published in: Cesk Slov Neurol N 2016; 79/112(5): 585-590
Category: Short Communication


In 2008, the new MG Composite score was constructed from selected items of existing scales of myasthenia (QMG, MMT-MG, MG-ADL). The aim of this study was to validate the Czech version of MGC and to check reliability of the new scale in a group of patients from the Neuromuscular Centre of the University Hospital in Brno.

The Czech translation of MGC was validated by forward-backward translation. Inter-rater reliability was assessed with 40 patients (during a routine outpatient visit or hospitalization). Patients were assessed independently by two neurologists on the same day within 10–60 min (SV and MCH).

Intra-class correlation coefficient was 0.989 (CI = 0.98–0.994). Regression analysis of our data did not prove any systemic bias of difference according to MGC score (p = 0.616). Spearman correlation coefficient for the absolute difference in MGC value and the mean MGC of individual patients was 0.561.

MG Composite is an effective tool for long-term monitoring of patients, evaluation of treatment effect and comparing data suitable for use in routine clinical practice.

Key words:
myasthenia – score – Quantitative Myasthenia Gravis

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


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