Current Corticosteroid Treatment in Brain Tumours


Authors: O. Kalita;  M. Vaverka;  L. Hrabálek
Authors‘ workplace: Neurochirurgická klinika LF UP a FN Olomouc
Published in: Cesk Slov Neurol N 2016; 79/112(5): 521-527
Category: Review Article

Overview

Considering that there is no curative treatment for the majority of malignant brain tumours, supportive therapy plays a very important role and treatment with corticosteroids is its integral part. The goal of corticosteroid therapy is to maintain adequate quality of life and functional self-sufficiency. Corticosteroids have been used to effectively treat oedema around brain tumours since 1960s. In addition to their antioedematous action, their antiemetic and antilymphocytic effect has been utilised in neurooncology. However, these positive impacts are accompanied by a range of adverse cardiovascular, muscular, and psychiatric effects. Despite the widespread use of corticosteroids in neurooncology, no relevant data have been available so far concerning their optimal and safe administration in this specific case. Although there has been a development in disease-modifying treatment modalities over the recent years, the prognosis of patients with brain tumours remain poor; therefore, maintaining an acceptable quality of life continues to be a priority. Rational corticosteroid prescription to minimise toxicity is one of the major factors affecting the quality of life in patients with brain tumours.

Key words:
brain tumours – corticosteroid treatment – adverse effects – quality of life

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


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