IL-6 Levels in the Cerebrospinal Fluid and their Association with Brain Oxygen Partial Pressure and Cerebral Vasospasm Development in Patients with Aneurysmal Subarachnoid Haemorrhage

Authors: K. Ďuriš 1,2;  E. Neuman 2;  V. Vybíhal 2;  V. Juráň 2;  J. Gottwaldová 3;  M. Kýr 4;  A. Vašků 1;  M. Smrčka 2
Authors‘ workplace: Ústav patologické fyziologie, LF MU, Brno 1;  Neurochirurgická klinika LF MU a FN Brno 2;  Oddělení klinické biochemie, LF MU a FN Brno 3;  Klinika dětské onkologie LF MU a FN Brno 4
Published in: Cesk Slov Neurol N 2016; 79/112(5): 573-578
Category: Original Paper


The aim of this study was to evaluate whether levels of IL-6 in the cerebrospinal fluid are associated with parameters of transcranial dopplermetry or brain oxygen partial pressure (PbtO2) in patients with subarachnoid haemorrhage.

Patients and methods:
Patients with aneurysmal subarachnoid haemorrhage, who were unconscious during the fourth day after the onset of bleeding, were enrolled in the study. We explored associations between levels of IL-6 in the cerebrospinal fluid as measured on the fourth day after subarachnoid hemorrhage and transcranial dopplermetry parameters or brain oxygen partial pressure meassured one day later.

A total of 20 patients were enrolled into this study. There was a trend to higher levels of IL-6 in patients with cerebral vasospasm (med: 3,544; 25%/75% = perc: 2,106/6,907 vs. med: 10,080; 25%/75% perc: 2,540/13,958; p = 0.0946), however, no correlation between the levels of IL-6 and mean velocities in magistral vessels was observed. There was a tendency to higher levels of IL-6 related to PbtO2 lower than 20 mm Hg (med: 2,860; 25%/75% perc.: 940/8,580 vs. med: 6,937; 25%/75% perc: 3,811/14,524, p = 0.0587) and there was a significant correlation between the levels of IL-6 and PbtO2 in our study group (rs = –0,626; p = 0.002).

In this study group, there was a correlation between levels of IL-6 in the cerebrospinal fluid and subsequent PbtO2 values at the beginning of the period representing the highest risk of delayed cerebral ischemia development. Based on these results we assume that IL-6 might be considered as a promising marker to predict risk of developing delayed cerebral ischemia.

Key words:
subarachnoid hemorrhage – infl ammation – interleukin-6 – brain tissue oxygen monitoring – Licox – transcranial doppler-metry – cerebral vasospasm

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


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