Barriers of Nervous System under Physiological and Pathological Conditions

Authors: J. Piťha
Authors‘ workplace: Neurologické oddělení, Krajská zdravotní, a. s. – Nemocnice Teplice, o. z. ;  Neurologická klinika 1. LF UK a VFN v Praze
Published in: Cesk Slov Neurol N 2014; 77/110(5): 553-559
Category: Review Article
doi: 10.14735/amcsnn2014553


Central and peripheral nervous systems are separated from the bloodstream by barrier structures that prevent free migration of water-soluble molecules through the tight junctions of the choroid plexus endothelial and epithelial cells. These barriers also play a role in the influx of essential molecules and elimination of xenobiotics. In recent years, differences and common features of the various barrier systems are being explored. Their disorders play a key role in a number of nervous system diseases. The present paper describes the structure and function of barrier systems under physiological and pathological conditions.

Key words:
blood brain barrier – blood nerve barrier – endotelial cells – astrocytes – pericytes

The author declare he has no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for bio­medical papers.


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