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Neutralising Antibodies and Myxovirus Resistance Protein A as a Marker of Biological Response to Interferon β


Authors: J. Libertínová 1;  E. Meluzínová 1;  V. Maťoška 2;  M. Zajac 3;  E. Hynčicová 1;  A. Tomek 1;  M. Bojar 1
Authors‘ workplace: Neurologická klinika 2. LF UK a FN v Motole, Praha 1;  Laboratoř molekulární diagnostiky Nemocnice Na Homolce, Praha 2;  Ústav lékařské mikrobiologie, 2. LF UK a FN v Motole, Praha 3
Published in: Cesk Slov Neurol N 2014; 77/110(5): 638-641
Category: Short Communication

Děkuji doc. MU Dr. Petrovi Marusičovi, Ph.D. za připomínky k článku. Podpořeno grantem IGA MZ ČR NT 12385- 5.

Overview

Interferon β is the first-line treatment for relapsing-remitting multiple sclerosis. Patients treated with interferon β may develop neutralizing antibodies that can reduce or abolish its efficacy. Interferon-inducible Myxovirus resistance protein A has been proven to be a sensitive marker of biological response to interferon β. Neutralizing antibodies and the levels of Myxovirus resistance protein A mRNA are sensitive measures of biological response to interferon β; their levels should be investigated in all interferon-treated patients.

Key words:
interferon b – multiple sclerosis – neutralizing antibodies – Myxovirus resistance protein A

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


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Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 5

2014 Issue 5

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