Dental Abnormalities after Treatment for Childhood Cancer

Authors: B. Mladosievičová 1;  R. Jurkovič 2;  L. Izakovičová Hollá 3,4
Authors‘ workplace: Oddelenie klinickej patofyziológie, LF UK Bratislava, Slovenská republika 1;  DEIMPERIO, spol. s r. o., Bratislava, Slovenská republika 2;  Stomatologická klinika LF MU a FN u sv. Anny v Brně 3;  Ústav patologické fyziologie, LF MU, Brno 4
Published in: Klin Onkol 2015; 28(1): 20-23
Category: Review
doi: 10.14735/amko201520


Childhood cancer therapy often increases the risk of dental complications, such as tooth and roots agenesis, microdontia, abnormal development of tooth enamel, increased risk of cavity and other abnormalities. In a comparison with other late adverse effects of chemotherapy, radiotherapy and hematopoietic stem cell transplantion, a relative small number of clinical stud­ies observing patients for more than two years after completion of anticancer treatment was published. In this article, we review the incidence of dental abnormalities caused by commonly used anticancer treatment modalities as well as discuss their risk factors. Early identification of high-risk patients, early detection and management of dental abnormalities and better education of patients or their guardians, may have an impact on quality of life of cancer survivors.

Key words:
chemotherapy – radiotherapy – late effects – tooth abnormalities – childhood cancer

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

3. 3. 2014

4. 12. 2014


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Paediatric clinical oncology Surgery Clinical oncology
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