Management of Patients with Castration‑resistant Metastatic Prostate Cancer


Authors: D. Ondruš 1;  M. Ondrušová 2,3
Authors‘ workplace: I. onkologická klinika LF UK a Onkologického ústavu sv. Alžbety, Bratislava, Slovenská republika 1;  Vysoká škola zdravotníctva a sociálnej práce sv. Alžbety, Bratislava, Slovenská republika 2;  Ústav experimentálnej onkológie SAV, Bratislava, Slovenská republika 3
Published in: Klin Onkol 2015; 28(1): 24-29
Category: Original Articles
doi: 10.14735/amko201524

Overview

Prostate cancer belongs to the most common malignant tumors in males. Almost in all patients in advanced stage, disease progression occurs despite of castration therapy. Initial treatment of metastatic disease is androgen deprivation therapy. In the case of castration‑resistant disease development in asymptomatic patients, it is a combination of abiraterone acetate plus prednisone and in symptomatic patients docetaxel with prednisone are considered gold standards at the present time. The aim of therapy must be assurance of adequate quality of life, pain reduction and survival improvement. The paper presents an overview of current castration‑resistant metastatic prostate cancer treatment.

Key words:
castration‑resistant prostate cancer –  androgen deprivation –  chemotherapy

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
29. 12. 2014

Accepted:
8. 1. 2015


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