Clinical Oncology - Issue Supplementum 3/2019

Editorial

3
Editorial 2019

Review

6
Uncommon EGFR Mutations in Non-Small Cell Lung Cancer and Their Impact on the Treatment

O. Bílek, M. Holánek, J. Berkovcová, O. Horký, T. Kazda, H. Čoupková, S. Špelda, L. Kristková, M. Zvaríková, J. Podhorec, S. Bořilová, L. Bohovicová, L. Zdražilová Dubská

13
CRISPR-Cas9 as a Tool in Cancer Therapy

P. Zatloukalová, R. Krejčíř, D. Valík, B. Vojtěšek

19
Synthetic Lethality – Its Current Application and Potential in Oncological Treatment

L. Bortlíková, P. Müller, B. Vojtěšek, V. Rak, M. Svoboda

25
Progress in the Utilisation of Organometallic Compounds in the Development of Cancer Drugs

H. Skoupilová, R. Hrstka

34
Overview of Current Findings about the Role of Oestrogen Receptor α in Cancer Cell Signalling Pathways

P. Voňka, R. Hrstka

39
Glycoproteins in the Sera of Oncological Patients

L. Hernychová, L. Uhrík, R. Nenutil, M. V. Novotný

46
Glycosylation as an Important Regulator of Antibody Function

L. Uhrík, L. Hernychová, B. Vojtěšek

56
Protein Ubiquitination Research in Oncology

J. Faktor, M. Pjechová, L. Hernychová, B. Vojtěšek

65
Long Non-Coding RNAs – Current Methods of Detection and Clinical Applications

L. Moráňová, M. Bartošík

72
Oncogenic Viral Protein Interactions with p53 Family Proteins

V. Brychtová, V. Hrabal, B. Vojtěšek

78
Cooperation of Genomic, Transcriptomics and Proteomic Methods in the Detection of Mutated Proteins

F. Zavadil Kokáš, J. Faktor, B. Vojtěšek


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