Levosimendan and renal function

Authors: F. Málek;  P. Ošťádal;  A. Krüger;  D. Vondráková;  J. Matoušková;  P. Neužil
Authors‘ workplace: Ambulance srdečního selhání a hypertenze ;  Kardiovaskulární centrum ;  Nemocnice Na Homolce, Praha
Published in: Kardiol Rev Int Med 2013, 15(3): 178-180


Decreased renal function is usually observed in patients with heart failure, the impaired kidney functions have a negative impact on the outcome and renal dysfunction is a limiting factor for the effect of optimal medical therapy. A short‑term renoprotective effect of Levosimendan was shown in hemodynamic studies. Other studies confirmed that the positive effect of Levosimendan on the kidney function is long‑term. This effect is explained by several mechanisms of action; besides redistribution of renal blood flow, Levosimendan also has an anti‑inflammatory effect.

heart failure –  Levosimendan –  renal function


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Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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