Importance of determining apolipoproteins B and A-1 in clinical practice


Authors: H. Vaverková
Published in: Kardiol Rev Int Med 2012, 14(3): 153-156
Category:

Overview

Apolipoproteins (Apo) are protein components of lipoprotein macromolecules. They fulfil various functions that can affect the destiny of lipoprotein particles, thus influencing the atherogenesis process. In terms of cli­nical practice, only the determination of ApoB has been of importance so far: ApoB is an indicator of the total number of atherogenic particles as well as a good surrogate marker of the number of small dense LDL (sdLDL). According to the ESC/EAS 2011 guidelines, ApoB should be considered an alternative risk marker in patients with combined hyperlipidemia, metabolic syndrome, diabetes and chronic kidney disease. In these patients, ApoB is also a secondary target indicator of treatment efficacy. Neither ApoA-1 nor the ApoB/ApoA-1 ratio is suitable for assessing treatment efficacy.

Keywords:
apolipoprotein B – apolipoprotein A-1 – LDL-cholesterol – cardiovascular risk – guidelines – lipid-lowering therapy


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Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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