Antidiabetic drugs and cardiovascular risk – before and now

Authors: M. Haluzík;  M. Urbanová;  P. Trachta
Published in: Kardiol Rev Int Med 2012, 14(3): 149-152


Cardiovascular complications are the major cause of morbidity and mortality of patients with type 2 diabetes mellitus. This is why the major aim of the complex treatment of these patients is to decrease their total cardiovascular risk. This view point plays an important role in assessing the effects of antidiabetic drugs in recent years. Long term studies have suggested that tight diabetes compensation early after diagnosis can decrease cardio­vascular risk. Much less is known about the effects of respective antidiabetic drugs on cardiovascular complications. From the classical antidiabetic drugs portfolio only metformin and in part pioglitazone has confirmed cardioprotective effects. Out of recently introduced antidiabetic therapies experimental and smaller clinical studies suggest a very good potential for incretin-based therapies i.e. gliptins or glucagon-like peptide 1 agonists. The effect of novel antidiabetic therapies on cardiovascular complications which is now being intensively explored within long-term studies will in near future undoubtedly become one of the leading decisive factors in the selection of antidiabetic treatment.

type 2 diabetes mellitus – antidiabetic treatment – cardiovascular complications – diabetes compensation


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Paediatric cardiology Internal medicine Cardiac surgery Cardiology
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