Sugammadex for active reversal of neuromuscular blockade induced by rocuronium for Caesarean section in general anaesthesia – series of case reports


Authors: Štourač Petr 1;  Kosinová Martina 1;  Bártíková Ivana 1;  Klučka Jozef 1;  Křikava Ivo 1;  Štoudek Roman 1;  Harazim Hana 1;  Huser Martin 2;  Janků Petr 2;  Gál Roman 1
Authors‘ workplace: Klinika anesteziologie, resuscitace a intenzivní medicíny FN Brno a LF MU, Brno 1;  Gynekologicko-porodnická klinika FN Brno a LF MU, Brno 2
Published in: Anest. intenziv. Med., 24, 2013, č. 3, s. 163-167
Category: Anaesthesiology - Case Report

Overview

Sugammadex is a selective relaxant-binding agent, which reverses rocuronium-induced neuromuscular blocks of any depth. We reported six Caesarean sec-tion cases undergoing general anaesthesia with propofol(1.6–2.3 mg/kg) or thiopental (4.1–5.6 mg/kg) and rocuronium (0.8–1.1 mg/kg) or sukcinylcholin(1.0–1.5 mg/kg) for the induction of neuromuscular blockade. Rocuronium was used for the maintenance of neromuscular blockade (0.4–0.5 mg/kg). At the end of the procedure, all the patients had a significant degree of neuromuscular block. In one patient, there was no single twitch response and no TOF-ratio, three patients had shallow neuromuscular blockade (TOF > 1) and two of them had no clinical signs of neuromuscular recovery (TOF monitoring not used). The same single dose of sugammadex 200 mg (1.7–3.2 mg/kg) was given. In all patients, sugammadex provided rapid and sufficient reversal to full muscle strenght. All patients were monitored after the operation and no signs of recurarization or neuromuscular weakness were observed.

Keywords:
sugammdex – Caesarean section – general anaesthesia – neuromusclar blockade – Rapid Sequence Induction


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Anaesthesiology, Resuscitation and Inten Intensive Care Medicine

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