Lung Changes as a Possible Result of Adverse Effects of Betalactam Antibiotics

Authors: M. Filaun 1;  I. Lišková 1;  J. Stejskal 2;  V. Mužíková 3;  O. Lochman 4;  E. Bébrová 4
Authors‘ workplace: Klinika AR 2. LF UK a IPVZ, FN Motol, přednosta doc. MUDr. K. Cvachovec, CSc. 1
Published in: Anest. intenziv. Med., , 2000, č. 5, s. 219-221


Authors refer to not much known adverse reaction in treatment with betalactam antibiotics. In years 1997 – 1998 there was 691 children treatedin our ICU, we found in 25 of them increased level of antibodies against betalactam antibiotics. Indication for examination of level antibodies wasX-ray picture of wet lung, contemporary application of betalactam antibiotics and somet imes positive allergic history. Antibodies was determined withmethod of non direct hemaglutination and as a positive finding was level 1:320 and more. In these cases was antibiotic treatment changed to antibioticsof other type. We found recess of X-ray picture in 20 cases, 5 children died. Histological inv estigation for evaluation of immunocomplexes C3 and IgGin the wall of alveoli was made immediately post mortem. Immunofluorescent investigation findings were positive in 4 cases. Authors recommend incase of worsening of lung changes to evaluate level of antibodies and replace betalactam antibiotics with antibiotics of other type.

Key words:
betalactam antibiotics – level of antibodies against betalactam antibiotics – adverse effect of antibiotics – immunofluorescent investigation

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Anaesthesiology, Resuscitation and Inten Intensive Care Medicine
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