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Efficacy and Safety of Single-Application Hyaluronic Acid in Osteoarthritis Therapy
Causal therapy for osteoarthritis does not yet exist. Patients suffering from progressive joint disease are thus dependent on symptomatic medications that alleviate symptoms and partially slow the progression of osteoarthritis. An essential role in therapy is played by viscosupplementation in the form of intra-articular application of hyaluronic acid (HA). Currently, 3rd generation preparations intended for single application are preferred due to their efficiency and safety.
Enoxaparin in Weight-Based Dosing for Thromboprophylaxis in Hospitalized Cancer Patients
Cancer patients are at higher risk of developing thromboembolic disease during hospitalization. Currently, there is not enough evidence supporting the efficacy and safety of the standard fixed dose…
Neoadjuvant Immunotherapy in Resectable Non-Small Cell Lung Cancer
Antibodies against the programmed cell death protein 1 (PD-1) improve the survival of patients with advanced non-small cell lung cancer (NSCLC). However, their use has not yet been tested in patients…
Impact of Alpha-1 Antitrypsin Deficiency on Quality of Life and Mental Health of Patients
The clinical manifestation of alpha-1 antitrypsin deficiency and its impact on quality of life are highly heterogeneous. This contribution by pulmonologist Robert Sandhaus summarizes interesting…
COVID-19 and Immune Thrombocytopenic Purpura − Spanish Experience Suggests Surprising Connections
In a retrospective study examining the impact of COVID-19 on immune thrombocytopenic purpura, Spanish authors surprisingly observed a paradoxical effect.
Care of Dental Dentures According to the Recommendations of the American Society of Dental Prosthetists
Dental dentures are the most common solution for missing teeth in the jaw. They should serve patients for several years, so proper care is essential. Therefore, dental professionals should not only…
Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract
Brazilian authors published a review of available information on the mechanism of action of metamizole, its impact on gastrointestinal tract motility, its effect on the gastric mucosa, and its…
Impact of Thyroid Dysfunction on the Cardiovascular System in Elderly Patients
The incidence of thyroid disease increases with age. In the Czech Republic, up to 5% of the population suffers from hypothyroidism, and the prevalence of hyperthyroidism is estimated at 0.2-1%. The…
Rurioctocog alfa pegol in previously treated patients with severe hemophilia A: What findings did the long-term continuation study bring?
Rurioctocog alfa pegol (Adynovi) is a recombinant coagulation factor VIII modified by pegylation, which results in an approximately 1.5× prolonged biological half-life compared to standard half-life…
Position of aPCC in the Treatment of Hemophilia A Complicated by the Development of Inhibitors
Activated prothrombin complex concentrates (aPCC) are essential drugs that not only allow the control of bleeding in patients with congenital hemophilia A and inhibitors but also help to prevent such…
Anxiety Disorders and Autoimmune Thyroiditis – A Connection Rather Than Coincidence?
Anxiolytics commonly target the central nervous system. Newly published research by Ukrainian authors offers a different perspective – according to their findings, anxiety may be related to thyroid…
Targeted Treatment and Quality of Life in Patients with Follicular Lymphoma
The GALLIUM clinical trial evaluated chemotherapy in combination with targeted treatment using rituximab or obinutuzumab in previously untreated patients with advanced follicular lymphoma (FL). A…
Sport Therapy as Part of Hemophilia Management
A study by authors from the University of Wuppertal in Germany specifically examined the impact of a half-year programmed sport therapy on the subjective physical performance and quality of life of…
EHL preparations have the potential to change the quality of life for people with hemophilia
Within the therapeutic modalities for hemophilia, the current era offers a number of preparations. Newer extended half-life (EHL) replacement therapies can provide hemophiliacs with better protection…
Idiopathic Thrombocytopenic Purpura with SARS-CoV-2 Infection
To date, 45 cases of idiopathic (autoimmune) thrombocytopenic purpura (ITP) in individuals with confirmed SARS-CoV-2 infection have been published in the literature. In September 2020, a review…
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