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Targeted Treatment of Metastatic Breast Cancer in the 2nd Line –⁠ Experiences from Practice

23. 11. 2020 Source: Breast Carcinoma

The recommended treatment for metastatic HER2-positive breast cancer in the 1st line involves dual blockade of the HER2 signaling pathway using trastuzumab and pertuzumab in combination with a taxane cytostatic. After the failure of this therapy, treatment with trastuzumab emtansine (T-DM1) is recommended. However, this recommendation is not supported by a prospectively designed controlled study examining the outcomes of this therapeutic sequence. Therefore, a group of Italian authors decided to publish the results of a patient cohort treated…

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Micronutrients in Parenteral Nutrition in Adult Patients –⁠ Current Issues and Consensus

Micronutrients are a key nutritional component, and this is also true for patients whose condition requires the administration of parenteral nutrition. An article published last year in the Journal…
23. 11. 2020 Source: Parenteral Nutrition
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Residual Pulmonary Hypertension After Endarterectomy: How Common Is It?

Pulmonary endarterectomy is the only potentially curative option in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH). What are its outcomes and in what percentage of cases does…
23. 11. 2020 Source: Pulmonary hypertension (CTEPH, PAH)
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Medium to Long-term Results of PFC Sigma Total Knee Arthroplasty

The PFC Sigma knee implant was introduced in 1997. It is the most commonly used system for total knee arthroplasty in England and Wales, accounting for 34.9% of primary implantations in 2006. Studies…
23. 11. 2020 Source: Large Joints
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Venous Insufficiency of the Lower Extremities –⁠ A Diverse Range of Risks, Manifestations, and Complications

Although initially often asymptomatic, chronic venous insufficiency includes a variety of symptoms. Some of its manifestations can be irreversible, increasing the socio-economic burden that this…
20. 11. 2020 Source: Venous Insufficiency

Geriatrics and Nutrition in Old Age -⁠ Invitation

We invite you to watch a webinar dedicated to the topic of nutrition in old age. The impetus for its creation was the fact that from September 1, 2020, physicians specializing in geriatrics are allowed...
19. 11. 2020 Source: Enteral Nutrition
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Effect of Zolpidem on the Quality of Overnight Sleep in Terms of Episodic Memory Formation

Zolpidem is a non-benzodiazepine hypnotic used for the short-term treatment of insomnia in adults. Previous studies have shown that this gamma-aminobutyric acid (GABA-A) agonist stimulates the…
19. 11. 2020 Source: Geriatric Patient
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Idiopathic Pulmonary Fibrosis: What Can a General Practitioner Do?

When a previously healthy patient becomes breathless, it's never good news. Among the particularly serious issues that breathlessness can signal is idiopathic pulmonary fibrosis (IPF). However, its…
19. 11. 2020 Source: Pulmonary Fibrosis
Případová studie pacienta

Direct Oral Anticoagulants and Their Reversal Agents –⁠ Current Options

In the last 10 years, the options for anticoagulant therapy have expanded with the introduction of direct oral anticoagulants (DOACs). It appears that DOACs may soon replace warfarin in the first…
19. 11. 2020 Source: Anticoagulant Treatment
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Two Is Not Enough: Efficacy of Alemtuzumab in Subsequent Cycles

The goal of the recent pooled analysis of the CARE-MS and TOPAZ study results published in the journal Multiple Sclerosis was to evaluate the efficacy and safety of alemtuzumab in patients with…
18. 11. 2020 Source: Multiple Sclerosis
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Different doses of LMWH in hospitalized patients with COVID-19 –⁠ interim experience

Many experts recommend administering heparin to patients with COVID-19 as part of anticoagulant prophylaxis, especially in severe forms of this infection. However, data on dosage, administration…
18. 11. 2020 Source: Thromboprophylaxis

Depakine Chrono versus Other Valproates in the Treatment of Bipolar Disorder

Bipolar disorder is among the most severe psychiatric illnesses, and if not treated properly, it can negatively affect the patient's quality of life. Does switching therapy from other valproates to…
18. 11. 2020 Source: Bipolar Disorder
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Efficacy of Romiplostim in Children with Persistent or Chronic ITP

The effect of the thrombopoietin receptor agonist romiplostim in adult patients with immune thrombocytopenia (ITP) is well known. Equally important, however, are data on its treatment in children —…
18. 11. 2020 Source: Immune Thrombocytopenia
Výsledky

Experiences with AHA in Two Czech Centers and Risk Factor Evaluation

This summer, the journal Haemophilia published the results of an analysis of data from a relatively large Czech cohort of patients with acquired hemophilia A (AHA). The goal was to identify risk…
18. 11. 2020 Source: Hemophilia

Therapy of Chronic Leg Ulcers According to Evidence-Based Medicine

Chronic ulcers on the lower extremities are defined as trophic defects that show no signs of healing after 3 months of appropriate treatment or are not healed even after 12 months of treatment. Their...
15. 11. 2020 Source: Wound Healing
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