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Can the Fixed Combination of Tramadol/Acetaminophen Significantly Reduce Back Pain Uncontrolled by NSAIDs?

9. 10. 2020 Source: Pharmacotherapy of Pain

One way to prevent drug-related complications in the treatment of lower back pain (LBP) while improving patients' functioning in daily activities is the prescription of the weak opioid agonist tramadol in combination with acetaminophen. A smaller Japanese observational study focused on the effectiveness of this treatment in reducing the disability of patients with chronic LBP, improving their daily activities, and the occurrence of adverse events.

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Brentuximab Vedotin and Relapsing/Refractory NHL with High Expression of CD30

A recently published study by authors from South Korea focused on examining the efficacy of brentuximab vedotin in patients with non-Hodgkin lymphomas (NHL) that highly express CD30 (i.e., > 30%…
7. 10. 2020 Source: Hematologic Malignancies
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New Natural Method for Prevention and Treatment of House Dust Mite Allergy

House dust mites are among the most common triggers of respiratory allergies. Until now, therapy has primarily focused on alleviating allergy symptoms. The aim of the new natural-based method is to…
6. 10. 2020 Source: Dust Mite Allergy
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Comparison of Pharmacological Properties of Micronized Diosmin and Hesperidin in the Treatment of Chronic Venous Insufficiency and Hemorrhoids

Diosmin and hesperidin belong to the group of bioflavonoids, which currently find wide application in the treatment of chronic venous insufficiency and hemorrhoidal disease. Both flavonoids have been…
6. 10. 2020 Source: Venous Insufficiency
Dítě s atopickou dermatitidou

Topically administered tacrolimus does not increase cancer risk in children with atopic dermatitis

Topical therapy using corticosteroids or calcineurin inhibitors forms the main component of treating atopic dermatitis (AD) in children and adolescents. Although these medications are applied…
6. 10. 2020 Source: Topical Treatment of Psoriasis
Aplikace masti

Are Topical Calcineurin Inhibitors Really Such Demons?

Some medications indeed have significant side effects, while others suffer from a bad reputation that is hard to dispel. Can we do something reasonable against this? Let's revisit or expand our…
6. 10. 2020 Source: Topical Treatment of Psoriasis
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Case Study of a Patient with NSCLC −⁠ with Voting

Presented by: MUDr. Leona Koubková, Pneumology Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague
5. 10. 2020 Source: Immunotherapy in Oncology
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Dupilumab –⁠ The First Biologic Umbrellaing Type 2 Inflammation Treatment: How Does It Work and Who Is It For?

A new drug is entering the market for the treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps –⁠ the biologic product Dupixent®. The active ingredient is dupilumab, a…
5. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
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Interaction of the 'Big Five' Helps Predict Depression

Experts refer to the 'Big Five' as a personality model that encompasses the following five dimensions: openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism. Can…
5. 10. 2020 Source: Depression and Anxiety
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Effect of 3 Different Doses of Trazodone on QT Interval Length

Patients diagnosed with depression often also suffer from cardiovascular diseases, including heart failure. Given the increased risk of death in such comorbid patients, the safety and efficacy of the…
5. 10. 2020 Source: Depression and Anxiety
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What Did the Patent for the Synthesis of Highly Purified Trazodone Bring?

Trazodone is a modern antidepressant that is used in the treatment of various types of depression, including those accompanied by anxiety, sleep disorders, or sexual dysfunction. Angelini's…
5. 10. 2020 Source: Depression and Anxiety
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Long-term Clinical and Radiological Results of Implantation of Cementless Corail Stem

The Corail femoral stem with extensive hydroxyapatite coating for cementless implantation was introduced to the market several decades ago. The study cited below evaluated the clinical and…
2. 10. 2020 Source: Large Joints

Immunotherapy of Cancer Diseases

Immunotherapeutic strategies have been successfully utilized recently in the treatment of various malignancies. Increasing understanding of the interactions between the tumor and the host organism over...
1. 10. 2020 Source: Immunotherapy in Oncology

Dynamics of Allergy Development in Children

The prevalence of allergic diseases in children in developed countries has been steadily increasing in recent decades. Slovak authors attempted to describe the dynamics of the development of allergic…
1. 10. 2020 Source: Allergic Reactions

Use of Bilastine in Pediatrics −⁠ Pathway to Improving Concentration and Performance of Young Allergy Sufferers

In the treatment of allergic diseases, especially in children, safety, good tolerability, simple dosing regimen, and non-sedative effects are the basic requirements for administered medications.…
1. 10. 2020 Source: Allergic Reactions
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