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The Anti-inflammatory and Renoprotective Effect of Candesartan May Be Independent of the AT1 Receptor

12. 8. 2021 Source: Sartans in the Treatment of Hypertension

Candesartan belongs to the blockers of AT1 receptors (AT1R) for angiotensin II coupled with G protein. The authors of the presented study found that the anti-inflammatory and renoprotective effect of candesartan persists even when the receptor is completely blocked. The aim of the further study was to clarify this mechanism -⁠ independent of AT1R.

bunka,geny,rakovina

Programmed Cell Death as a Therapeutic Target in Chronic Lymphocytic Leukemia

One of the key steps in malignant transformation is the disruption of apoptosis. Tumor cells exploit a variety of mechanisms that allow them to evade programmed cell death. Among the drugs targeting…
10. 8. 2021 Source: Chronic Lymphocytic Leukemia
medicína_lékař_mikroskop_studie_výzkum_laboratoř

Teriflunomide vs. Dimethyl Fumarate in Real Practice: We Know the Winner! Will It Surprise You?

Teriflunomide and dimethyl fumarate are disease-modifying drugs (DMDs) used in the treatment of multiple sclerosis (MS). Regarding the course, form, and severity of MS, their target groups are comparable...
31. 7. 2021 Source: Multiple Sclerosis
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MS, NMOSD and COVID-19: What Did a Year of Pandemic in Czechia Mean for Our Patients and Which Risk Factors Were Confirmed?

What is the incidence and course of COVID-19 in patients with multiple sclerosis (MS) and diseases from the broader spectrum of neuromyelitis optica (NMOSD) in Czechia? And which risk factors pertain...
28. 7. 2021 Source: Multiple Sclerosis
NSCLC

Intracranial Activity of Lorlatinib in Patients with Metastatic ALK-Positive NSCLC

Lorlatinib is a potent third-generation anaplastic lymphoma kinase (ALK) inhibitor with significant antitumor activity against non-small cell lung cancer (NSCLC). According to the results of an…
23. 7. 2021 Source: Genetic Profile and Treatment of NSCLC
animace léky zkumavka výzkum laborator

Experiences with treating PBC with obeticholic acid in Brno's CKTCH

MUDr. Libuše Husová, Ph.D., shared the current insights from the therapy of patients with primary biliary cholangitis (PBC) using obeticholic acid (OCA) gained at the Center for Cardiovascular and Transplantation...
22. 7. 2021 Source: Primary Biliary Cholangitis
tennager kardiologie 2

Dabigatran Etexilate in the Treatment of Acute Thromboembolic Disease in Children

Until now, standard anticoagulants such as low-molecular-weight heparin or unfractionated heparin and others have been used in pediatric patients for the treatment of thromboembolism. The study…
22. 7. 2021 Source: Anticoagulant Treatment
nemocnice tým lékařů schůzka porada

When to Stop Dabigatran Anticoagulation Treatment Before Catheter Ablation in Patients with Atrial Fibrillation?

Catheter ablation is now a standard method of treating atrial fibrillation. Its most common complications are bleeding and thromboembolism. The aim of the analysis of 2 clinical studies presented…
22. 7. 2021 Source: Anticoagulant Treatment
peřina přikrývka postel

Dust Mite Allergies: Common Does Not Mean Trivial

Dust mite allergies are almost ubiquitous problems that we perceive as part of the 'broader norm.' However, patients do not see it this way, so we should not lose sight of it.
22. 7. 2021 Source: Dust Mite Allergy
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OCA in Second-Line Treatment of PBC: Analysis Results and Real-World Data

Ursodeoxycholic acid (UDCA) is the cornerstone treatment for PBC according to the guidelines of the European Association for the Study of the Liver (EASL). However, many patients (25–50%) do not achieve...
21. 7. 2021 Source: Primary Biliary Cholangitis
alergie_dítě_louka_kapesník

Bilastine as a reliable helper in the treatment of allergic rhinoconjunctivitis and urticaria even in younger children

Until recently, bilastine was indicated for the treatment of allergic rhinoconjunctivitis and urticaria only in patients over 12 years of age. However, current findings from valid studies demonstrate…
21. 7. 2021 Source: Allergic Reactions
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Key for Patients with PBC are Timely Diagnosis and Assessment of Therapy Effectiveness

Primary biliary cholangitis (PBC) cannot be cured. It progresses slowly and over several decades leads to liver cirrhosis with all its potential consequences, including possible transplantation and the...
19. 7. 2021 Source: Primary Biliary Cholangitis

Von Willebrand Disease as a Cause of Abnormal Uterine Bleeding

Abnormal uterine bleeding constitutes a large portion of complaints among women of reproductive age. This type of bleeding is typical for von Willebrand disease (vWD), but also for other types of…
16. 7. 2021 Source: Von Willebrand Disease
Schizofrenie_barevnéhlavy

Negative Symptoms of Schizophrenia and Their Assessment

Schizophrenia is a serious psychiatric disorder with a prevalence of up to 1%. It can manifest with both negative and positive symptoms. We briefly summarize the clinical assessment and rating scales…
14. 7. 2021 Source: Schizophrenia and Antipsychotics
srovnani_leku_porovnavani_lecba_ucinna_latka_dva_leky

Dabigatran vs. Warfarin: What and Why Do Patients Prefer?

The key to adherence to long-term anticoagulant therapy is primarily the satisfaction of patients with the set therapy. The RE-SONANCE study published in April 2021 compared patient satisfaction with…
1. 7. 2021 Source: Anticoagulant Treatment
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