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Key for Patients with PBC are Timely Diagnosis and Assessment of Therapy Effectiveness

19. 7. 2021 Source: Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) cannot be cured. It progresses slowly and over several decades leads to liver cirrhosis with all its potential consequences, including possible transplantation and the risk of premature death. The foundation of PBC pharmacotherapy is ursodeoxycholic acid (UDCA) and in recent years, obeticholic acid (OCA) has also been available, which European and Czech guidelines recommend as the second-line treatment. One of the symposiums at this year's XLVIII May Hepatology Days also focused on PBC and its therapy, including...

Von Willebrand Disease as a Cause of Abnormal Uterine Bleeding

Abnormal uterine bleeding constitutes a large portion of complaints among women of reproductive age. This type of bleeding is typical for von Willebrand disease (vWD), but also for other types of…
16. 7. 2021 Source: Von Willebrand Disease
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Negative Symptoms of Schizophrenia and Their Assessment

Schizophrenia is a serious psychiatric disorder with a prevalence of up to 1%. It can manifest with both negative and positive symptoms. We briefly summarize the clinical assessment and rating scales…
14. 7. 2021 Source: Schizophrenia and Antipsychotics
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Dabigatran vs. Warfarin: What and Why Do Patients Prefer?

The key to adherence to long-term anticoagulant therapy is primarily the satisfaction of patients with the set therapy. The RE-SONANCE study published in April 2021 compared patient satisfaction with…
1. 7. 2021 Source: Anticoagulant Treatment
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New Recommendations for Intravenous Thrombolysis in the Treatment of Acute Ischemic Stroke –⁠ ESO Guidelines 2021

Intravenous thrombolysis is the only approved systemic reperfusion therapy for patients with acute ischemic stroke (AIS). The most commonly used thrombolytic is alteplase. Earlier this year, the…
1. 7. 2021 Source: Anticoagulant Treatment
plíce virus a bakterie

Alpha-1 Antitrypsin Deficiency and Lung Disease in Patients with Primary Immunodeficiencies

Alpha-1 antitrypsin deficiency (AATD) plays a significant role in the pathogenesis of pulmonary emphysema, chronic obstructive pulmonary disease (COPD), and bronchiectasis. However, its deficiency…
1. 7. 2021 Source: Deficiency of Alpha-1-Antitrypsin

Can identifying alpha-1 antitrypsin deficiency before liver transplantation extend survival?

Alpha-1 antitrypsin deficiency (AATD) can manifest (among other things) as liver cirrhosis. The study presented below examined the survival of patients diagnosed with AATD before and after liver…
1. 7. 2021 Source: Deficiency of Alpha-1-Antitrypsin
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Expression of PD-L1 as a Predictive Biomarker for Therapy Selection in mRCC

A newly published systematic review and meta-analysis of studies involving patients with metastatic renal cell carcinoma (mRCC) evaluates the predictive significance of PD-L1 expression in the…
1. 7. 2021 Source: Kidney Carcinoma
dotazník pacientka nemocnice pece

Efficacy and Safety of Axitinib in Higher Lines of Renal Carcinoma Treatment in Real Practice

Greek authors published a retrospective study from a single institution and demonstrated that axitinib is a safe and effective treatment option for metastatic renal carcinoma even in ≥ 3rd line…
26. 6. 2021 Source: Kidney Carcinoma
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Cardiovascular Risks in Schizophrenics: What Are They Related To and How To Eliminate Them?

Schizophrenia affects about 1% of the population. This disease is associated, among other things, with increased cardiovascular (CV) morbidity and mortality. What is the cause and what to focus on in…
24. 6. 2021 Source: Modern Treatment of Schizophrenia
metabolismus

Impact of Lurasidone on Metabolic Functions Compared to Other Antipsychotics –⁠ Results of a Large Meta-Analysis

Antipsychotic therapy is associated with varying degrees of metabolic abnormalities in parameters of weight, lipid metabolism, and glucose metabolism. The presence of metabolic syndrome or isolated…
24. 6. 2021 Source: Modern Treatment of Schizophrenia
plice rozhovor lekar pacient v ordinaci muz

Lung Recovery After COVID-19: How Reversible is the Damage?

During the virtual XXV Hradec Pulmonology Days held in April 2021, various aspects concerning COVID-19 were among the major topics. Dr. Bram van den Borst from Radboud University Nijmegen provided a comprehensive...
22. 6. 2021 Source: proLékaře.cz

Reducing Cardiovascular Risk in Diabetics Through Hypertension Treatment

The presence of hypertension in patients with diabetes worsens overall cardiovascular (CV) prognosis and increases the prevalence of chronic renal failure. Adequate treatment of hypertension can…
21. 6. 2021 Source: Diabetes
irritable bowel syndrome

Irritable Bowel Syndrome and Non-specific Inflammatory Bowel Diseases Are Not Evolutionarily Related Diseases

The authors of the presented work attempted to compare the geographical distribution of irritable bowel syndrome and non-specific inflammatory bowel diseases and other factors related to these two diseases...
19. 6. 2021 Source: Irritable Bowel Syndrome
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Can antihypertensive treatment also have a beneficial effect on neurocognitive functions?

Observational studies suggest that a desirable side effect of AT1 receptor blockers for angiotensin II (sartans) could be cognitive protection of patients. A randomized study published last year…
14. 6. 2021 Source: Sartans in the Treatment of Hypertension
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