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New Recommendations for Intravenous Thrombolysis in the Treatment of Acute Ischemic Stroke –⁠ ESO Guidelines 2021

1. 7. 2021 Source: Anticoagulant Treatment

Intravenous thrombolysis is the only approved systemic reperfusion therapy for patients with acute ischemic stroke (AIS). The most commonly used thrombolytic is alteplase. Earlier this year, the European Stroke Organisation (ESO) issued new evidence-based recommendations for this clinical situation. They contain 40 points, summarized below are the most important ones.

Alpha-1 Antitrypsin Deficiency and Lung Disease in Patients with Primary Immunodeficiencies

Alpha-1 antitrypsin deficiency (AATD) plays a significant role in the pathogenesis of pulmonary emphysema, chronic obstructive pulmonary disease (COPD), and bronchiectasis. However, its deficiency…

1. 7. 2021 Source: Deficiency of Alpha-1-Antitrypsin

Can identifying alpha-1 antitrypsin deficiency before liver transplantation extend survival?

Alpha-1 antitrypsin deficiency (AATD) can manifest (among other things) as liver cirrhosis. The study presented below examined the survival of patients diagnosed with AATD before and after liver…

1. 7. 2021 Source: Deficiency of Alpha-1-Antitrypsin

Expression of PD-L1 as a Predictive Biomarker for Therapy Selection in mRCC

A newly published systematic review and meta-analysis of studies involving patients with metastatic renal cell carcinoma (mRCC) evaluates the predictive significance of PD-L1 expression in the…

1. 7. 2021 Source: Kidney Carcinoma

Efficacy and Safety of Axitinib in Higher Lines of Renal Carcinoma Treatment in Real Practice

Greek authors published a retrospective study from a single institution and demonstrated that axitinib is a safe and effective treatment option for metastatic renal carcinoma even in ≥ 3rd line…

26. 6. 2021 Source: Kidney Carcinoma

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Cardiovascular Risks in Schizophrenics: What Are They Related To and How To Eliminate Them?

Schizophrenia affects about 1% of the population. This disease is associated, among other things, with increased cardiovascular (CV) morbidity and mortality. What is the cause and what to focus on in…

24. 6. 2021 Source: Modern Treatment of Schizophrenia

Impact of Lurasidone on Metabolic Functions Compared to Other Antipsychotics –⁠ Results of a Large Meta-Analysis

Antipsychotic therapy is associated with varying degrees of metabolic abnormalities in parameters of weight, lipid metabolism, and glucose metabolism. The presence of metabolic syndrome or isolated…

24. 6. 2021 Source: Modern Treatment of Schizophrenia

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Lung Recovery After COVID-19: How Reversible is the Damage?

During the virtual XXV Hradec Pulmonology Days held in April 2021, various aspects concerning COVID-19 were among the major topics. Dr. Bram van den Borst from Radboud University Nijmegen provided a comprehensive...

22. 6. 2021 Source: COPD

Reducing Cardiovascular Risk in Diabetics Through Hypertension Treatment

The presence of hypertension in patients with diabetes worsens overall cardiovascular (CV) prognosis and increases the prevalence of chronic renal failure. Adequate treatment of hypertension can…

21. 6. 2021 Source: Diabetes

Irritable Bowel Syndrome and Non-specific Inflammatory Bowel Diseases Are Not Evolutionarily Related Diseases

The authors of the presented work attempted to compare the geographical distribution of irritable bowel syndrome and non-specific inflammatory bowel diseases and other factors related to these two diseases...

19. 6. 2021 Source: Irritable Bowel Syndrome

Can antihypertensive treatment also have a beneficial effect on neurocognitive functions?

Observational studies suggest that a desirable side effect of AT1 receptor blockers for angiotensin II (sartans) could be cognitive protection of patients. A randomized study published last year…

14. 6. 2021 Source: Sartans in the Treatment of Hypertension

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Are there mutual interactions between candesartan and amlodipine in the combination therapy of hypertension?

Monotherapy is often insufficient in the treatment of hypertension; however, combining antihypertensives with different mechanisms of action can be complicated by their mutual interactions.…

14. 6. 2021 Source: Sartans in the Treatment of Hypertension

INFOGRAPHIC: LDL Cholesterol -⁠ Recommended Target Values

Elevated levels of LDL cholesterol are a significant risk factor for cardiovascular diseases, which remain the most common cause of death among adult Czechs. We have strong evidence about who and how...

11. 6. 2021 Source: Chronic Heart Failure and Lipidology

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How did alemtuzumab fare in real clinical practice?

A study published by authors from the University of Massachusetts in January this year in the journal Multiple Sclerosis and Related Disorders focused on the effectiveness and safety of alemtuzumab.…

11. 6. 2021 Source: Multiple Sclerosis

Reduction of LDL Cholesterol in the Prevention of Cardiovascular Morbidity and Mortality –⁠ Results of a Large Meta-Analysis

Elevated LDL cholesterol (LDL-c) is one of the main causes of atherosclerosis. The meta-analysis presented below examined the effect of reducing its levels on the risk of cardiovascular (CV)…

11. 6. 2021 Source: Chronic Heart Failure and Lipidology

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