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Compression Therapy with Zinc Oxide Dressings in Dermatology

10. 5. 2023 Source: Wound Healing

Zinc oxide dressings have a long-standing tradition and continue to find their place in modern dermatology. Compression therapy is the cornerstone of conservative treatment for chronic venous insufficiency and lymphatic insufficiency and should not be overlooked even at the stage of venous leg ulcers.

Metamizole in Pain Management for Patients with Subarachnoid Hemorrhage

A study by Czech authors from the University Hospital St. Anna in Brno, recently published in the British Journal of Neurosurgery, evaluated analgesic treatment in patients with subarachnoid…

10. 5. 2023 Source: Analgesia

Comparison of the Effectiveness of Different Types of Toothbrushes in Orthodontic Patients

The aim of the study cited below was to evaluate the efficiency of a manual orthodontic brush, an electric toothbrush with an oscillating head, and a sonic toothbrush in controlling plaque,…

10. 5. 2023 Source: Dental Care

Efficacy and Safety of Ozanimod in the Treatment of Relapsing-Remitting MS

The sphingosine-1-phosphate receptor (S1PR) modulator ozanimod has recently been approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). We summarize the current knowledge…

9. 5. 2023 Source: Modulation of S1P in the Treatment of Autoimmune Diseases

Ozanimod Expands Treatment Options for Ulcerative Colitis in Adult Patients

As a review article published last year in the journal Drugs suggests, ozanimod is an effective and well-tolerated medication for adult patients with moderate to severe ulcerative colitis (UC), both…

9. 5. 2023 Source: Modulation of S1P in the Treatment of Autoimmune Diseases

Ozanimod in Induction and Maintenance Therapy for Ulcerative Colitis −⁠ True North Study Results

Ozanimod is a selective modulator of the sphingosine-1-phosphate receptor (S1PR) approved for the treatment of ulcerative colitis (UC) in adult patients. We summarize the results of the phase III…

9. 5. 2023 Source: Modulation of S1P in the Treatment of Autoimmune Diseases

Prognostic Significance of Mutations in Maintenance Hypomethylation Therapy for AML Patients

A recently published sub-analysis of the QUAZAR AML-001 clinical trial evaluated the efficacy of maintenance treatment for acute myeloid leukemia (AML) with oral azacitidine, considering the initial…

9. 5. 2023 Source: proLékaře.cz

Current Recommendations by the ELN Expert Panel on AML Diagnosis Management

The 2022 recommendations from European LeukemiaNet (ELN) add new information to the previous recommendations from 2010 and 2017. They concern the diagnosis and treatment of acute myeloid leukemia…

9. 5. 2023 Source: Acute Myeloid Leukemia

Overuse of Corticosteroids as a Serious Problem in ITP

Corticosteroids (CS) are a common part of the treatment for immune thrombocytopenia (ITP). However, their administration is associated with significant short-term and long-term toxicity, and the goal…

9. 5. 2023 Source: Immune Thrombocytopenia

Romiplostim in Life-Threatening Bleeding Situations −⁠ Case Reports

Immune thrombocytopenic purpura, or immune thrombocytopenia (ITP), typically manifests as bleeding due to a low platelet count. Some bleeding episodes can be life-threatening or fatal. Clinical…

9. 5. 2023 Source: Immune Thrombocytopenia

CYP Enzyme? Cytochrome P450 2D6 and Drug Metabolism

The CYP2D6 isoenzyme of cytochrome P450 participates in the metabolism of approximately 20% of commonly used drugs. Genetic variants of this enzyme are very common, leading to significant inter-individual...

5. 5. 2023 Source: Genetics

Association of M2 Haplotype of the Annexin A5 Gene with Recurrent Reproductive Losses

Annexin A5 (ANXA5) is a placental anticoagulant protein that ensures adequate blood supply to the fetus during pregnancy, and its deficiency can increase the incidence of vascular thrombosis in the…

5. 5. 2023 Source: Genetics

Etiology of Recurrent Reproductive Losses –⁠ Focus on Genetics

Repeated pregnancy losses pose a significant threat to a woman's physical and mental health. The etiology of up to half of these cases remains unexplained, and recurrent reproductive losses are…

4. 5. 2023 Source: Genetics

Li-Fraumeni Syndrome –⁠ Indication for Testing and Recommended Surveillance

A germline mutation of the TP53 gene, which causes Li-Fraumeni syndrome, results in a congenital predisposition to the occurrence of malignant tumors, such as pediatric malignancies, breast cancer, bone...

3. 5. 2023 Source: Genetics

Water Microjet as a Gentler Method of Debridement

Debridement is an integral part of chronic wound treatment. Currently, the most common method is mechanical debridement, which involves the use of sharp tools or abrasive materials to remove necrotic…

3. 5. 2023 Source: Wound Healing

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