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Oral Azacitidine Prolongs Survival of AML Patients Regardless of Measurable Residual Disease
6. 6. 2023 Source: Acute Myeloid LeukemiaIntensive chemotherapy for patients newly diagnosed with acute myeloid leukemia (AML) often achieves high remission rates, although these remissions are often only temporary. Consolidation therapy with azacitidine (AZA) extends post-remission survival and disease-free intervals.
Vaccination and ALEmtuzumab: ALE when?
When, why and against what should patients with multiple sclerosis treated with alemtuzumab be vaccinated? And is vaccination effective in this population?5. 6. 2023 Source: Multiple Sclerosis
Traveling with MS – Is Vaccination a Limitation?
What about the need for vaccination when traveling abroad? Which vaccines should you be cautious about? And how to time vaccination concerning disease activity and the individual medications used in…5. 6. 2023 Source: Multiple Sclerosis
Can Ketogenic Diet or Intermittent Fasting Help Patients with DM2 in Controlling Weight and Glycemia?
The foundation of managing type 2 diabetes mellitus (DM2) typically involves lifestyle adjustments, including dietary changes. Can intermittent fasting (IF) or the ketogenic diet (KD), popular…30. 5. 2023 Source: Modern Treatment of Diabetes
New Type of Fixation Allows Regular Limb Hygiene and Stay in Water
Conservative therapy for injuries and non-traumatic diseases of the musculoskeletal system is a daily reality in surgical and orthopedic clinics. An important part of treatment is limb fixation, most…26. 5. 2023 Source: proLékaře.cz
Predictors and Rate of Anticoagulant Therapy Discontinuation in Patients with Atrial Fibrillation
With the worldwide increase in the prevalence of atrial fibrillation (AF), the use of anticoagulants (warfarin, DOACs – direct oral anticoagulants) to reduce the risk of ischemic stroke (iCMP) is…25. 5. 2023 Source: Anticoagulant Treatment
Association Between Sartan Therapy and Lower Incidence of Epilepsy in Hypertensive Patients?
Arterial hypertension (AH) is one of the non-cerebral comorbidities of epilepsy, with the renin-angiotensin system possibly being the central mediator of the connection between these diseases. The…25. 5. 2023 Source: Sartans in the Treatment of Hypertension
RETRO-TAS Study – Trifluridine/Tipiracil in Pretreated mCRC in Real-World Practice
How does trifluridine/tipiracil (FTD/TPI), which demonstrated efficacy in clinical trials in chemotherapy-refractory metastatic colorectal cancer (mCRC), fare in real-world practice? This was…25. 5. 2023 Source: Treatment of Gastrointestinal Carcinomas
Study TACTIC – Efficacy and Safety of Trifluridine/Tipiracil in Pre-treated mCRC Patients in Real-world Practice
In the pivotal phase III RECOURSE randomized placebo-controlled study, therapy with trifluridine/tipiracil (FTD/TPI) was associated with improved overall survival and progression-free survival in…25. 5. 2023 Source: Treatment of Gastrointestinal Carcinomas
Sotorasib in the Treatment of a Patient with NSCLC and DIC – A Case Report
Sotorasib is the first clinically used inhibitor of the KRAS oncogene with the G12C mutation. Its efficacy in the targeted treatment of non-small cell lung cancer (NSCLC) is still under research, but…24. 5. 2023 Source: Lung Cancer
Incidence of Brain Metastases and Intracranial Activity of Sotorasib in Patients with NSCLC with G12C Mutation of the KRAS Oncogene
Sotorasib is the first targeted drug approved for the treatment of metastatic non-small cell lung cancer (NSCLC) with the G12C mutation of the KRAS oncogene. The newly published study presented below…24. 5. 2023 Source: Lung Cancer
“Customized Schizophrenia Treatment”: Benefits of Therapeutic Innovations in Inpatient and Outpatient Care Thanks to Gentler Antipsychotics
In the field of schizophrenia treatment, the possibility of significantly greater individualization, brought about by gentler antipsychotics, is currently a hot topic. A major focus is the…24. 5. 2023 Source: Modern Treatment of Schizophrenia
Angiodysplasia as a Serious Problem in Patients with von Willebrand Disease − Case Study
Bleeding into the gastrointestinal tract can become a very significant cause of morbidity and mortality in patients with von Willebrand disease (vWD). It has been described that gastrointestinal (GI)...19. 5. 2023 Source: Von Willebrand Disease
Pharmacotherapy of Glaucoma in a Nutshell According to the Latest Recommendations of the European Glaucoma Society
The European Glaucoma Society published its latest, 5th version of recommendations for the treatment of glaucoma in 2021. The following text, based on these recommendations, focuses in a nutshell on the...18. 5. 2023 Source: Treatment of Glaucoma
Model of Risk of Bleeding Associated with Physical Activity in Hemophiliacs with Factor and Non-Factor Treatment
In the treatment of hemophilia A, both FVIII concentrate replacement therapy and non-factor therapy are available today. However, there is no clinical data comparing the risk of bleeding associated…18. 5. 2023 Source: Hemophilia
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