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vyzkum biologie

Treatment for Transthyretin Cardiac Amyloidosis is Now More Accessible to Czech Patients

15. 6. 2023 Source: Amyloidosis

Transthyretin cardiac amyloidosis is a serious progressive disease that was until recently considered untreatable. In recent years, however, new treatment options targeting the underlying pathology of the disease have emerged, which, along with advances in non-invasive diagnostics, offer patients hope for a longer and better-quality life.

Starší muž s karpálním tunelem

TTR amyloidosis –⁠ at the crossroads of cardiology and orthopedics

In wild-type transthyretin amyloid cardiomyopathy, extra-cardiac symptoms occur in addition to cardiac symptoms. Common and characteristic orthopedic manifestations include bilateral carpal tunnel…
14. 6. 2023 Source: Amyloidosis
myokardu

Clinical Profile and Outcomes of Patients with Cardiac Amyloidosis –⁠ Spanish Experience from Real Practice

Cardiac amyloidosis is caused by the deposition of amyloid fibrils in the myocardium and is among the diseases with significant diagnostic delay. Physicians from the University Hospital in Madrid…
14. 6. 2023 Source: Amyloidosis
atopická dermatitida na ruce

Meta-analysis of the efficacy and safety of dupilumab in the treatment of atopic dermatitis in children and adults

Moderate to severe atopic dermatitis (AD) is accompanied by strong inflammatory processes that can occur anywhere on the skin, intense itching, and pain. The biologic dupilumab is a promising…
13. 6. 2023 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
data report

Nonacog Beta Pegol (N9-GP) in Bleeding Prophylaxis in Patients with Hemophilia B –⁠ Real World Data

The goal of hemophilia B treatment is currently the prevention of bleeding by administering a coagulation factor IX concentrate. The study presented below brings recent real-world data on treatment…
13. 6. 2023 Source: Hemophilia with Movement
lymfom dlbcl

Comparison of BEAM and TEAM Conditioning Regimens Before Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Lymphomas

At the beginning of this year, one of the few studies comparing the most commonly used conditioning regimen before autologous hematopoietic stem cell transplantation (ASCT) in patients with lymphomas…
13. 6. 2023 Source: Oncological Treatment
Human heredity

Deficit dihydropyrimidine dehydrogenase and its association with 5-fluorouracil toxicity

Deficit dihydropyrimidine dehydrogenase (DPD) is a risk factor for severe toxicity of 5-fluorouracil (5-FU). Below, we summarize current knowledge regarding the identification of patients with…
12. 6. 2023 Source: Genetics
žíly na nohách

Compression therapy in combination with surgical intervention in the treatment of venous leg ulcers and prevention of their recurrence

Compression therapy represents an important part of the treatment of venous leg ulcers; it also plays a role in preventing possible recurrences. The 4-year British ESCHAR study evaluated the impact…
12. 6. 2023 Source: Wound Healing
operace_karcinom

Combination of Targeted Therapy with Chemo in 1st Line in Patients with Left-Sided wtRAS mCRC

The preferred targeted therapy added to the combination with standard chemotherapy (CHT) for left-sided metastatic colorectal cancer (mCRC) with non-mutated RAS oncogene should be an antibody against…
9. 6. 2023 Source: Colorectal Cancer
oncology

Osteonecrosis of the Jaw Associated with Antiresorptive Pharmacotherapy in Oncological Patients

Antiresorptive pharmacotherapy in the form of bisphosphonates and denosumab is associated, according to current knowledge, with the risk of jaw osteonecrosis, especially following dental procedures…
8. 6. 2023 Source: Prevention of Bone Events
lekar_pacient

Prediction of Hypocalcemia Risk in Patients Treated with Denosumab and Active Form of Vitamin D

According to new work by Japanese authors, it appears that the risk factors for the development of hypocalcemia in patients treated with denosumab and calcitriol (the active form of vitamin D) are…
8. 6. 2023 Source: Prevention of Bone Events
metaanalýza

Meta-analysis of Efficacy and Safety of Third-Generation Antiseizure Medications in Adjunctive Treatment of Focal Seizures in Adults with Epilepsy

Epilepsy treatment is primarily symptomatic, aimed at reducing seizure frequency. However, more than 50% of patients do not achieve seizure freedom with monotherapy. Below we summarize the results of…
8. 6. 2023 Source: Epilepsy
Epilepsie léky

How Does Cenobamate Compare with Third-Generation Anti-Seizure Medications in Terms of Cost-Effectiveness?

The main goal of epilepsy treatment is to achieve seizure freedom without unacceptable side effects of therapy. Despite the benefits of the latest generation of anti-seizure medications (ASMs),…
8. 6. 2023 Source: Epilepsy
lung diseases rheumatism

Comparison of the Risk of Interstitial Lung Disease in Patients with RA with Biological and Targeted Disease-Modifying Antirheumatic Therapy

The authors of a newly published study sought to answer whether the risk of developing interstitial lung disease in patients with rheumatoid arthritis (RA) is affected by the administration of…
8. 6. 2023 Source: Arthritis
leukémie stará žena

Effect of Azacitidine in the Treatment of Acute Myeloid Leukemia on Long-Term Patient Survival

The work cited below presents freshly updated results from the Quazar AML-001 study evaluating azacitidine (AZA) in the treatment of acute myeloid leukemia (AML), now with a median follow-up period…
6. 6. 2023 Source: Acute Myeloid Leukemia
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