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Adherence to Treatment of Multiple Sclerosis: How to Enhance It and What Interesting Insights Emerged from Current Research?

24. 4. 2023 Source: Multiple Sclerosis

Therapeutic options for patients with multiple sclerosis (MS) utilizing disease-modifying drugs (DMDs) have continued to expand in recent years. However, achieving their full benefit is critically dependent on adherence to treatment. Nonadherence is demonstrably linked to an increased risk of relapses, faster progression of disability, higher treatment costs, and higher mortality. We present a summary of factors affecting adherence to treatment in MS patients, including the influence of the chosen therapy from a 2022 review and subsequent studies.

Teriflunomide in the Treatment of RRMS: The Best Working Drug Is the One That the Patient Actually Takes

Teriflunomide is an oral disease-modifying drug (DMD) used in the therapy of relapsing-remitting multiple sclerosis (RRMS). The authors of the cited American study assessed adherence to this treatment...

24. 4. 2023 Source: Multiple Sclerosis

Early Tumor Regression as a Marker of Overall Survival in First-Line Treatment of mCRC

In the treatment of metastatic colorectal cancer (mCRC), prognostic factors besides overall survival (OS) and progression-free survival (PFS) include early tumor regression (ETS) and depth of…

21. 4. 2023 Source: Colorectal Cancer

Meta-Analysis of the Results of Studies Comparing the Effectiveness of Manual and Sonic Toothbrushes

Brushing teeth is a fundamental means of maintaining good oral hygiene. While many people still rely on using manual toothbrushes, brushing with electric toothbrushes has also gradually gained…

21. 4. 2023 Source: Dental Care

Is Obesity a Universal Phenotype in Children with Type 2 Diabetes?

What is the global prevalence of obesity in children and adolescents suffering from type 2 diabetes mellitus (T2DM)? Does the occurrence of obesity in pediatric T2DM correlate with gender or race?…

19. 4. 2023 Source: Modern Treatment of Diabetes

Echocardiography in the Diagnosis of Cardiac Amyloidosis

Cardiac amyloidosis remains a diagnostic challenge that requires great clinical vigilance. The imaging method of choice for evaluating heart failure suspected of amyloidosis is echocardiography. What…

17. 4. 2023 Source: Amyloidosis

Diagnosis and Management of Therapy for a Breastfeeding Patient with Significant Elevation of Liver Enzymes Postpartum –⁠ Interactive Case Study

In the following case study, we present a specific approach to a patient who developed a significant elevation of liver enzymes after childbirth. Through interactive elements, you can try out how you...

14. 4. 2023 Source: Primary Biliary Cholangitis

Empagliflozin will be funded from May for symptomatic heart failure regardless of EF LK value

Empagliflozin entered the market as an antidiabetic drug operating on the principle of reducing glucose reabsorption by the kidneys from the urine and increasing its excretion through urine. Thanks…

14. 4. 2023 Source: Heart Failure

Closeup růžovo-bílá a modro-bílá antibiotika kapsle

Current View on Obstacles in Proper Use of Antibiotics and the Role of Biomarkers in Infection Diagnosis

In the fight against antibiotic resistance, principles for the proper use of antibiotics (ATB) have been introduced globally. The following overview briefly describes the obstacles in leading…

13. 4. 2023 Source: Anti-Infectives

Screenings of Lung Cancer and COPD are Significant. What Do the Latest Data from Czechia Say?

At the end of January, an expert seminar was held, focusing on updates in the treatment of respiratory diseases. During this event, the head of the Pulmonary Clinic at LF UK and FN Hradec Králové, …

12. 4. 2023 Source: Cough Therapy

Measurement of Serum Trough Levels of IgG as an Adequate and Beneficial Indicator for Assessing the Pharmacokinetics of Subcutaneously Administered Products

For many patients with primary immunodeficiency, lifelong immunoglobulin substitution is essential to reduce the frequency of severe infections. Subcutaneous home administration is better accepted by...

11. 4. 2023 Source: Primary and Secondary Immunodeficiencies

Dosing and Consumption of rFVIII Products with Extended Half-life in Patients with Hemophilia A in Real-World Practice

Based on real-world data from the USA, a recently published study compared two recombinant human factor VIII (rFVIII) products with extended half-life (EHL) –⁠ efmoroctocog alfa and rurioctocog alfa…

11. 4. 2023 Source: Hemophilia

Ligamentous Changes as a Harbinger of Cardiac Amyloidosis –⁠ Histopathological and Clinical Study

Amyloid deposits can be present in various types of tissue. Their accumulation in connective tissue can lead to pathological changes resulting in the rupture of stressed structures (e.g., the…

10. 4. 2023 Source: Amyloidosis

AAD 2023: Efficacy of Bimekizumab in the Treatment of Hidradenitis Suppurativa

At the latest annual congress of the American Academy of Dermatology (AAD), held March 17-22, 2023 in New Orleans, the results of the phase III BE HEARD I and II studies were presented among …

7. 4. 2023 Source: Psoriasis

Efficacy and Safety of Ultrahypofractionated Proton Therapy in the Treatment of Prostate Cancer in Real-World Czech Practice

A team from the Prague Proton Therapy Center, led by Associate Professor Jiří Kubeš, published a study with nearly 300 patients in the prestigious International Journal of Radiation Oncology,…

5. 4. 2023 Source: Proton Radiotherapy

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