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Characteristics of Patients with Alpha-1 Antitrypsin Deficiency –⁠ Two-Year Data from the EARCO Registry

28. 6. 2023 Source: Deficiency of Alpha-1-Antitrypsin

The international registry of individuals with alpha-1 antitrypsin deficiency (AATD) named EARCO has collected data on 1,044 patients from 15 countries, including the Czech Republic, over its first 2 years of existence. In December 2022, the characteristics of patients enrolled from February 2020 to May 2022 were published. They provide information on the prevalence of AATD genotypes, their clinical phenotypes, factors associated with worsening lung function, and the impact of augmentation therapy.

operace

Postpartum Uterine Artery Pseudoaneurysm in a Woman with vWD –⁠ Case Study

Women with von Willebrand disease (vWD) have a significantly higher risk of postpartum hemorrhage. American experts from University Hospital in Augusta have published their experience with an unusual…
28. 6. 2023 Source: Von Willebrand Disease
mycoplasma test

Nucleic Acid Amplification Tests in the Diagnosis of Sexually Transmitted Diseases

Based on 81 scientific papers published between 2010 and 2021, experts from Johns Hopkins University in Baltimore have prepared an overview of the current epidemiology, diagnosis, and treatment of…
28. 6. 2023 Source: Genetics
žilni tromboemboloie

How to Reduce the Risk of Venous Thromboembolism in Users of Combined Hormonal Contraceptives?

The use of combined oral contraceptives (COCs) is a known risk factor for thromboembolism. Therefore, we should consider the individual risk of each patient before prescribing COCs. Women with a…
27. 6. 2023 Source: Genetics
prim. Miroslav Nečas

What is new in the treatment of atopic dermatitis and how are comorbidities affecting it?

Allergic rhinitis, conjunctivitis, bronchial asthma, or autoimmune diseases like alopecia, vitiligo, celiac disease, and idiopathic inflammatory bowel diseases –⁠ these are comorbidities that often…
26. 6. 2023 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
ulcerative colitis33

Tofacitinib in the Treatment of Ulcerative Colitis in Real-World Practice in the USA

A recently published study summarizes the characteristics of patients newly treated with tofacitinib for ulcerative colitis (UC), the impact of initiating tofacitinib on corticosteroid use, and…
22. 6. 2023 Source: Intestinal Inflammations
pneumokok

Expanded Vaccination Option Against Pneumococci Thanks to 15valent Vaccine

Our arsenal for preventing pneumococcal diseases has been expanded with a 15-valent conjugate vaccine that includes important serotypes causing invasive pneumococcal diseases (IPD). The following…
20. 6. 2023 Source: Regular Vaccination
karcinomplic

Change in Mutation Characteristics of NSCLC Detected by Liquid Biopsy –⁠ Case Study

Due to changes in mutations during the progression of metastatic non-small cell lung cancer (NSCLC) or to assess treatment response, liquid biopsy is essential for monitoring, as its results can…
19. 6. 2023 Source: Lung Cancer
detail běžeckých bot

Sports in People with Hemophilia –⁠ Possible and Safe

Active involvement in sports and an active lifestyle are important aspects of daily functioning for people with hemophilia. Modern treatment of this disease, including the prophylactic administration…
19. 6. 2023 Source: Hemophilia with Movement
Srdeční tlak

Analysis of Data from the EMPEROR-Preserved Study Revealed Whether Blood Pressure Affects the Effectiveness of Empagliflozin in Patients with Heart Failure with Preserved Ejection Fraction

Hypertension is among the most common etiological factors of heart failure with preserved ejection fraction (HFpEF), where pressure overload of the left ventricle leads to its eccentric hypertrophy…
19. 6. 2023 Source: Heart Failure
vyzkum biologie

Treatment for Transthyretin Cardiac Amyloidosis is Now More Accessible to Czech Patients

Transthyretin cardiac amyloidosis is a serious progressive disease that was until recently considered untreatable. In recent years, however, new treatment options targeting the underlying pathology…
15. 6. 2023 Source: Amyloidosis
Starší muž s karpálním tunelem

TTR amyloidosis –⁠ at the crossroads of cardiology and orthopedics

In wild-type transthyretin amyloid cardiomyopathy, extra-cardiac symptoms occur in addition to cardiac symptoms. Common and characteristic orthopedic manifestations include bilateral carpal tunnel…
14. 6. 2023 Source: Amyloidosis
myokardu

Clinical Profile and Outcomes of Patients with Cardiac Amyloidosis –⁠ Spanish Experience from Real Practice

Cardiac amyloidosis is caused by the deposition of amyloid fibrils in the myocardium and is among the diseases with significant diagnostic delay. Physicians from the University Hospital in Madrid…
14. 6. 2023 Source: Amyloidosis
atopická dermatitida na ruce

Meta-analysis of the efficacy and safety of dupilumab in the treatment of atopic dermatitis in children and adults

Moderate to severe atopic dermatitis (AD) is accompanied by strong inflammatory processes that can occur anywhere on the skin, intense itching, and pain. The biologic dupilumab is a promising…
13. 6. 2023 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
data report

Nonacog Beta Pegol (N9-GP) in Bleeding Prophylaxis in Patients with Hemophilia B –⁠ Real World Data

The goal of hemophilia B treatment is currently the prevention of bleeding by administering a coagulation factor IX concentrate. The study presented below brings recent real-world data on treatment…
13. 6. 2023 Source: Hemophilia with Movement
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