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News Characteristics of Chronic Wounds Related to Itching During Healing

Itching of wounds during healing is associated with larger wound size, more extensive tissue swelling, and the presence of granulation and necrotic tissue at the base. This was shown by an observational descriptive American study with 200 patients.

Source: Wound Healing 11. 5. 2020

News How and What the National AATD Register Benefits Experts and Patients

Given that alpha-1-antitrypsin deficiency (AATD) is still not receiving enough attention, it is necessary to raise professional awareness of this hereditary disease by all means. This is also one of the goals of the National AATD Register, which collects patient data to monitor the progression of the disease, identify the most suitable prognostic markers, and monitor the presence or progression of other organ impairments in these patients.

Source: Deficiency of Alpha-1-Antitrypsin 25. 2. 2022

Články časopisu Splanchnic vein thrombosis

Author of the article: Sylva Lajzová, Radek Kroupa, Alena Buliková, Šárka Bohatá, Barbora Packová, Michal Šenkyřík Source: Vnitřní lékařství | 3/2018 27. 4. 2018

Články časopisu Splanchnic vein closures

Author of the article: Z. Krška, J. Kvasnička, J. Hořejš, D. Hoskovec Source: Rozhledy v chirurgii | 6/2019 9. 7. 2019

News Dosing of Enoxaparin in Morbidly Obese Patients

How to optimally dose enoxaparin in morbidly obese patients? This question was addressed by a randomized study, the results of which were published in the journal Annals of Pharmacotherapy.

Source: Thromboprophylaxis 11. 11. 2021

News Metformin with Extended Release in the Treatment of Prediabetes

The benefit of metformin in preventing the development of diabetes in people with prediabetes has been demonstrated in clinical studies. However, these studies evaluated immediate-release metformin, not its extended-release form (XR). Therefore, the results of an observational study conducted at Polish and Hungarian centers, which examined the efficacy and safety of metformin XR in patients with prediabetes, are important in this context. It is also necessary to add that in our country, no drug containing this active substance has yet received an approved indication for the therapy of patients with prediabetes.

Source: Modern Treatment of Diabetes 2. 11. 2022

Články časopisu Asthma bronchiale in the context of internal medicine

Author of the article: Milan Teřl Source: Vnitřní lékařství | 11/2017 2. 1. 2018

News Effect of Itopride on Esophageal Motility and Lower Esophageal Sphincter Function

Itopride is a prokinetic used in the therapy of functional non-ulcerous upper dyspeptic difficulties. The mechanism of action involves inhibition of acetylcholinesterase and antagonism at dopamine D2 receptors. A clinical study by Belgian authors from the Catholic University of Leuven evaluated whether the effect of itopride is due to its influence on esophageal motility and lower esophageal sphincter function.

Source: Gastrointestinal Treatment 21. 4. 2020

News Echocardiography in the Diagnosis of Cardiac Amyloidosis

Cardiac amyloidosis remains a diagnostic challenge that requires great clinical vigilance. The imaging method of choice for evaluating heart failure suspected of amyloidosis is echocardiography. What findings are typical for patients with amyloidosis?

Source: Amyloidosis 17. 4. 2023

News When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?

Myasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle weakness and fatigability that worsens after physical exertion or mental stress. Accurate diagnosis is essential because treatment can lead to permanent remission and full functional capacity of the patient.

Source: Rare Diseases in Neurology 2. 5. 2023

News Non-Invasive Diagnosis of Cardiac Amyloidosis

Cardiac amyloidosis has always been considered a rare pathology. However, thanks to advancements in imaging methods and laboratory tests, it is now evident that it might be responsible for a larger amount of cardiac diseases than previously thought. Which non-invasive diagnostic methods are useful in identifying cardiac amyloidosis?

Source: Amyloidosis 16. 1. 2023

News News in Laboratory Diagnostics of Early Sepsis −⁠ First Czech Experiences

Sepsis represents one of the most frequent causes of morbidity and mortality in critically ill patients. Laboratory markers play an important role in the diagnosis and prognosis of septic states. The aim of the study by the Czech authors was to evaluate the diagnostic yield of new laboratory markers in the form of monocyte distribution width and specific markers on the surface of neutrophil granulocytes.

Source: Because 29. 11. 2021

News How to recognize amyloidosis as a cause of heart failure?

Although the fate of patients with heart failure has improved in recent decades, it remains a disease with a poor prognosis that significantly worsens the quality of life. The prevalence of heart failure is 1-2% in the adult population, but it increases with age and is more than 10% in people over 70. In addition to well-known causes, some rare nosological units, such as amyloidosis, can also be behind the development of heart failure.

Source: Amyloidosis 24. 2. 2022

News Updated Recommendations for Treatment of von Willebrand Disease

In 2021, new recommendations for the therapy of von Willebrand disease (vWD) were published, based on a consensus by the American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation (NHF), and the World Federation of Hemophilia (WFH). The recommendations comprise a total of 12 points and address not only prophylaxis but also gynecological and obstetric issues, for example.

Source: Von Willebrand Disease 28. 4. 2022

Články časopisu Cholangiocarcinoma: a pathologist’s point of view

Author of the article: J. Hrudka, E. Sticová Source: Rozhledy v chirurgii | 10/2022 8. 11. 2022