Search results: (10000)
News Care of Surgical Wounds and Choice of Dressings − Main Findings of the Latest International Expert Consensus
In December 2022, Wounds International published a summary of consensus outputs from six international expert meetings dedicated to postoperative care of surgical wounds and the selection of their dressings.
News Definition and Classification of Chronic Kidney Disease According to KDIGO
We provide a brief overview of the definition and classification of chronic kidney disease based on the updated KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guidelines from 2012 (published in 2013).
News Alternative to benzodiazepines or clomethiazole in the treatment of alcohol withdrawal syndrome?
Alcohol withdrawal syndrome (AWS) is a potentially life-threatening condition. A meta-analysis published in the journal Pharmacopsychiatry in September 2019 examines the effect of the combination of tiapridal and carbamazepine in the treatment of AWS. Is this combination a viable alternative to benzodiazepines or clomethiazole?
News Prof. Petr Marusič: Is the Success of Therapy Changing with the Arrival of New Antiepileptics?
At the XXV. postgraduate course in epileptology, 'Jiří Dolanský Days', prof. MUDr. Petr Marusič, Ph.D., from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University, and Motol University Hospital, lectured on the topic of changes in the efficacy of epilepsy treatment with the arrival of new anti-seizure medications.
News Efficacy and Safety of Ozanimod in the Treatment of Relapsing-Remitting MS
The sphingosine-1-phosphate receptor (S1PR) modulator ozanimod has recently been approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). We summarize the current knowledge on its mechanism of action and the results of available studies evaluating its efficacy and safety.
News Ozanimod Expands Treatment Options for Ulcerative Colitis in Adult Patients
As a review article published last year in the journal Drugs suggests, ozanimod is an effective and well-tolerated medication for adult patients with moderate to severe ulcerative colitis (UC), both in the initial phase of treatment and in the maintenance phase after achieving remission.
News Two Current Perspectives on the Importance of (Par)enteral Nutrition in Cancer Patients
Adequate (par)enteral nutrition is crucial for cancer patients in terms of prognosis and quality of life. The following recent studies examined parenteral nutrition as an alternative to ileostomy in patients with colorectal anastomosis and muscle mass loss in patients with metastatic cancer.
News Direct Oral Anticoagulants and Their Reversal Agents – Current Options
In the last 10 years, the options for anticoagulant therapy have expanded with the introduction of direct oral anticoagulants (DOACs). It appears that DOACs may soon replace warfarin in the first line of prevention of venous thromboembolism, not only due to their clinical advantages but also thanks to newly available reversal agents that can be administered in case of major bleeding in patients taking DOACs. A recently published review article summarizes the current situation in this area.
News MUDr. Petra Garnolová: The combination of medical cannabis with other analgesics is the ideal way to achieve the best effect with the fewest side effects
Medical cannabis is gradually finding its way to many patients with various ailments, including those with unmanageable and hard-to-influence chronic pain. For them, this therapy can offer a new chance at a quality life despite severe or terminal illness. A relatively new form that brings additional benefits is the extract of medical cannabis. We spoke with MUDr. Petra Garnolová, a specialist in clinical oncology and palliative medicine, about why it is worth considering not only as part of analgesic therapy and her experiences from real practice.
News How Diabetes Shortens Life or Mortality of Patients with Type 2 Diabetes
Type 2 diabetes mellitus (DM) has a significant impact on overall mortality across age categories. Who is most affected by this disease in terms of age and gender, and what are the current trends in mortality among the diabetic population?
News Pitfalls of Levothyroxine Replacement Therapy
Hypothyroidism (reduced function of the thyroid gland) affects approximately 1-2% of the population. Its prevalence increases with age and it is more common in women. Synthetic thyroid hormone levothyroxine is used to treat hypothyroidism. It is a widely prescribed medication available in tablets of various strengths.
News Proton radiotherapy in patients with nasopharyngeal carcinoma increases chances of successful treatment
Nasopharyngeal carcinoma mainly affects younger people. It tends to be aggressive but responds very well to treatment – up to 85% of patients with this diagnosis can achieve long-term tumor disappearance with proton radiotherapy, and a significant portion of patients even completely recover. The two-year treatment results for patients with very advanced nasopharyngeal tumors, which confirmed these conclusions, were published 2 years ago by a team from Prague's Proton Therapy Center (PTC).
News Current Indication Criteria for Testing Mutations in BRCA1 and BRCA2 Genes in Breast and Ovarian Cancer
Testing the mutation status of the BRCA1/2 genes can be beneficial for prevention, and in the case of already detected breast and/or ovarian cancer, also for direct treatment. We provide a brief overview of the current recommendations for testing based on the 2019 NCCN (National Comprehensive Cancer Network) guidelines and the recommended procedures of the Society of Medical Genetics ČLS JEP.
News Innovative Form of Levothyroxine Ensures Accurate Dosing for Patients
In the treatment of hypothyroidism, precise dosing of replacement therapy is critical. An innovative formulation of levothyroxine has been developed to meet the updated, stricter standards of regulatory authorities, thereby ensuring the desired therapeutic effect.
News Effect of Short-Term and Long-Term Stress on Heart Rate Variability
Acute and chronic stress significantly affects the cardiovascular (CV) system. The study presented below examines the effects of both acute and chronic stress on heart rate variability in 50 healthy individuals.