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News Quality of Nutrition in ICU and Subsequent Quality of Life Are Closely Related
In the past decade, there has been a reduction in mortality associated with severe sepsis or acute respiratory failure. However, the number of people requiring care in rehabilitation facilities, moving to nursing homes, and never returning home has tripled. Therefore, experts' attention should now and in the future more intensively focus on the quality of life of patients, not just indicators such as mortality. Properly chosen nutrition contributes significantly to patients leaving intensive care units with good prospects for further recovery.
News Focused on the Effect of Teriflunomide on Lymphocyte Subpopulations
Teriflunomide is a common choice for long-term therapy of the relapsing-remitting form of multiple sclerosis. The use of this immunomodulatory agent results in a decrease in lymphocyte numbers. Its effect on different lymphocyte subpopulations, however, has not been fully elucidated. Italian authors of a study published in the journal Neurology: Neuroimmunology and Neuroinflammation attempted to refine this knowledge.
News Are All Patients Really Suitable for Thromboprophylaxis Treated This Way?
A study published this year aimed to assess how often the risk of VTE is assessed in routine clinical practice in internally ill patients, what proportion of patients are suitable for thromboprophylaxis, and how many actually receive this treatment.
News Forgotten Pulmonologists: COVID-19 Detection in Patients with Lung Disease
The Czech Pneumological and Phthisiological Society of ČLS JEP (ČPFS) submitted a request to the Ministry of Health of the Czech Republic on March 25, 2020, to allow pulmonologists to send patients with suspected COVID-19 directly for infection testing. In their statement, they also provide recommendations on how to manage care for patients with chronic lung diseases during the outbreak of the SARS-CoV-2 virus and how these patients should behave.
News The Presence of COPD Worsens the Course of COVID-19 – Results of Epidemiological Studies
Among the at-risk populations during the current COVID-19 pandemic are older individuals and those suffering from chronic comorbidities. The presence of chronic obstructive pulmonary disease (COPD), according to available data, represents a negative prognostic factor increasing the risk of severe course and mortality.
News New Era in Migraine Therapy
Migraine is the most common type of primary headache. It affects about 10% of the world population. Recurring migraine attacks significantly reduce quality of life. Therefore, research in pharmacotherapy in recent years has logically focused on preventing attacks. The result is the latest possibility of biological treatment for migraines using monoclonal antibodies against CGRP receptors.
News Observational Study of Pegylated rVIII Administration in Real Clinical Practice
A recently published article by American hematologists provided valuable information about the treatment with pegylated recombinant factor VIII (rVIII) in real clinical practice. This is the most extensive observational study to date that evaluates the clinical effect of the treatment and at the same time compares the consumption of FVIII in people with hemophilia A who have changed medication from normal half-life (SHL) or extended half-life (EHL) concentrates to pegylated rVIII.
News Cost-effectiveness in Bleeding Control for Acquired Hemophilia A
A pharmacoeconomic analysis showed favorable cost-effectiveness of activated prothrombin complex concentrate in the indication of bleeding control in patients with acquired hemophilia A.
News Satisfaction of Patients Treated with Platinum Derivatives with Antiemetic Therapy
The fixed oral combination of netupitant with palonosetron (NEPA) is used for the prevention of nausea and vomiting induced by cytotoxic chemotherapy. A prospective German study evaluated the benefit of this therapy on the quality of life of patients treated with platinum derivatives.
News Simple antiemetic prophylaxis for breast cancer patients treated with AC chemotherapy
The combination of an anthracycline cytostatic agent with cyclophosphamide (AC) is among the highly effective chemotherapy regimens for breast cancer. Individually, these cytostatic agents carry a moderate risk of emetogenicity; however, when combined, they are considered to be at high risk of emesis. The recommended prophylaxis involves administering a 5-HT3 serotonin receptor antagonist in combination with an NK1 neurokinin receptor antagonist and the corticosteroid dexamethasone.
News Effect of Zolpidem on Sleep Quality and Other Parameters in Patients During the Perioperative Period
Sleep quality is an important factor influencing functional outcomes, pain intensity, and patient satisfaction during the perioperative period. Sleep disturbances are a common problem among patients post-surgery. A prospective study evaluated the effect of zolpidem on sleep quality and other parameters in patients undergoing total hip arthroplasty for advanced osteoarthritis.
News Use of Tiapride in the Treatment of Behavioral Disorders in Geriatric Patients
Hand in hand with the increasing number of people reaching an older age, there is also a rise in the occurrence of dementia. It affects the lives of patients and their families in many ways. A significant problem can be behavioral disorder, which needs to be treated adequately and promptly to prevent issues such as injuries.
News Trifluridine/tipiracil, regorafenib, or supportive therapy? Factors affecting the success of mCRC treatment
Currently, there are no biomarkers available to help decide, for a specific patient with refractory metastatic colorectal cancer (mCRC), whether therapy with trifluridine/tipiracil or regorafenib will be more effective and which patients will benefit the most from the treatment. A group of Czech oncologists presented the results of their analysis on this topic at the Gastrointestinal Symposium of the American Society of Clinical Oncology (ASCO) held in January 2020 in San Francisco.
News Sustained Remission of ITP with Thrombopoietin Receptor Agonists Treatment
Thrombopoietin receptor agonists (TPO-RAs) are highly effective drugs administered in chronic immune thrombocytopenia (ITP). Several studies have shown that they can induce remission and long-term response, even after prolonged discontinuation.
News Impact of Primary Tumor Location and Early Regression on Survival in Patients with Metastatic CRC
Results from recent clinical studies suggest the prognostic significance of the primary tumor location on the survival of patients with metastatic colorectal cancer (mCRC). A retrospective analysis of data from a single-arm open-label phase II clinical trial evaluated the impact of primary tumor location and its early regression (ETS - early tumor shrinkage) on the survival of patients with mCRC who received a combination of chemotherapy (FOLFIRI regimen) and targeted biological therapy (panitumumab).