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News Prof. Petra Lišková: Prevention of Dry Eye Syndrome is Difficult but Not Impossible

Dry eye syndrome is one of the most common ophthalmological problems, and its incidence is rising. Ophthalmologist Prof. MUDr. Petra Lišková, Ph.D., from the Clinic of Pediatrics and Hereditary Metabolic Disorders of the First Faculty of Medicine, Charles University, and University Hospital in Prague, explains how these difficulties arise and why patients should visit an eye doctor rather than relying solely on self-treatment.

Source: Ophthalmologic Diseases 13. 3. 2023

News Expanded Hemodialysis and Its Impact on Reducing Hospitalization Rates and Medication Usage

The number of patients with end-stage kidney disease is increasing. New approaches and technological advancements in recent decades have contributed to improving hemodialysis treatment. Does the use of so-called expanded hemodialysis lead to better outcomes?

Source: Chronic Kidney Disease 30. 11. 2021

Články časopisu Importance of Centric Relation Registration by the Patients with Complete Dentures
(Practical Report)

Author of the article: I. Voborná, L. Foltasová, K. Francová, Ľ. Harvan Source: Česká stomatologie / Praktické zubní lékařství | 2/2016 10. 6. 2016

Články časopisu What the assessment physician should know about patients on dialysis

Author of the article: E. Pauchová Source: Revizní a posudkové lékařství | 1-2/2019 18. 6. 2019

News ID 360 –⁠ Immunodeficiency in Interdisciplinary Collaboration 2022

For the second time, a two-day meeting titled "ID 360 –⁠ Immunodeficiency in Interdisciplinary Collaboration" took place, this time on March 25–26, 2022, in Prague. Several current topics were discussed during this professional event, which brings together experts who care for patients with primary or secondary immunodeficiencies. The meeting was professionally guaranteed by Prof. MUDr. Anna Šedivá, DSc., from the Institute of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital Motol in Prague.

Source: Primary and Secondary Immunodeficiencies 13. 5. 2022

News Comparison of the Effect of Sonic and Manual Toothbrushes on Dental Plaque and Gingivitis Control

A clinical study on healthy volunteers with mild to moderate gingivitis compared the effectiveness of sonic and manual toothbrushes in terms of dental plaque and gingivitis occurrence. The results of the study showed that the sonic toothbrush outperformed the manual one in all observed parameters.

Source: Dental Care 16. 2. 2023

News Prognostic Significance of Lymphopenia for Stratification of Patients with Follicular Lymphoma

The therapy of follicular lymphoma (FL) is guided by several prognostic indices, such as the Follicular Lymphoma International Prognostic Index (FLIPI). The retrospective analysis of 736 patients with FL presented below introduces a prognostic model combining FLIPI and absolute lymphopenia into an integrated FLIPI-L index. Absolute lymphopenia is crucial for stratifying patient OS and the risk of transformation.

Source: Non-Hodgkin Lymphomas and CLL 17. 3. 2020

News Efficacy and Safety of the Combination of Telmisartan and Amlodipine with Hydrochlorothiazide in the Treatment of Hypertension

The aim of the study by Korean authors was to evaluate the efficacy and tolerability of the triple combination of telmisartan/amlodipine + hydrochlorothiazide (TAH) compared to the combination of telmisartan/amlodipine (TA) alone in patients with essential hypertension who did not respond sufficiently to a 4-week treatment with TA.

Source: Sartans in the Treatment of Hypertension 8. 2. 2022

News Current Trends in Proton RT of Head and Neck Tumors: Aiming to Preserve T Lymphocytes, Without Them, Treatment is Ineffective

Tumors of the head and neck are often diagnosed at an advanced stage. With the availability of modern treatments, such as immunotherapy or radiotherapy modalities, prognosis and chances for long-term survival are improving. We discuss trends not only in proton therapy for oropharyngeal tumors and the prospects of combining treatment methods for these diagnoses with the head doctor of the Proton Center Prague Associate Professor MUDr. Jiří Kubeš, Ph.D.

Source: Proton Radiotherapy 10. 6. 2024

News Transthyretin Amyloidosis in Patients with Carpal Tunnel Syndrome

Carpal tunnel syndrome is considered a warning sign for cardiac amyloidosis. Amyloid deposits are often found in the tenosynovial material removed during surgery. However, the prevalence of concomitant cardiomyopathy is not yet fully understood. Japanese researchers from Kumamoto University recently focused on the relationship between carpal tunnel syndrome and cardiac amyloidosis in their newly published prospective study.

Source: Amyloidosis 10. 11. 2023

News Screening using NGS in patients with metastatic NSCLC –⁠ initial results from the ALK-positive cohort

Next-generation sequencing (NGS) allows for obtaining a large amount of information about the tumor genome from a patient's blood sample. Currently, the method is recommended as an alternative in cases of insufficient tissue samples for standard biopsy examination. The first results of an ongoing prospective study provide insights into the role of NGS in mutation screening for patients with non-small cell lung cancer without a concurrent biopsy examination.

Source: Genetic Profile and Treatment of NSCLC 1. 11. 2021

News Use of Testosterone Level as a Biomarker for Quality of Life in Patients with Prostate Cancer

In the treatment of prostate cancer, in addition to surgical treatment, stereotactic body radiotherapy (SBRT) and hormone therapy are also used. Androgen deprivation therapy (ADT) blocks the action or production of male sex hormones and is indicated for the treatment of intermediate and high-risk prostate cancers, where it reduces the risk of metastasis and prolongs survival. The work of experts from several American institutions monitored testosterone levels during therapy and their connection to the development of quality of life scores.

Source: Oncological Treatment 6. 12. 2023

Články časopisu Renal denervation –⁠ future or disappointment

Author of the article: T. Mikušová, Z. Stárek, J. Jež, F. Lehar, L. Špinarová Source: Kardiologická revue – Interní medicína | 1/2014 28. 2. 2014

News Enoxaparin in Weight-Based Dosing for Thromboprophylaxis in Hospitalized Cancer Patients

Cancer patients are at higher risk of developing thromboembolic disease during hospitalization. Currently, there is not enough evidence supporting the efficacy and safety of the standard fixed dose of low molecular weight heparin in individuals at high risk of thromboembolic disease. Therefore, a Phase II clinical study evaluated the efficacy and safety of weight-adjusted dosing in these patients.

Source: Thromboprophylaxis 6. 11. 2020

News Treatment of Depression with Persistent Severe Insomnia −⁠ Interactive Case Study

A 39-year-old patient comes to the psychiatric office due to depressive symptoms with anxiety and insomnia. He is worried about failing at work, also concerned about psychopharmaceuticals and their side effects, and is in psychotherapeutic care.

Source: Depression and Anxiety 11. 8. 2022