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News Adequate Compensation of a Hypertensive Patient According to Current ESC Guidelines – Case Study
A 65-year-old man, hypertensive, visits the general practitioner for a check-up. He reports recent shortness of breath during mild exertion (walking up stairs). Two months ago, he had acute sinusitis, for which he was prescribed antibiotics (penicillin V) by a specialist. He experiences hip pain and suffers from a runny nose in the spring (allergy?). He has been treated for hypertension for approximately 8 years.
News What has clinical research on the effects of inosin pranobex revealed, and what does it mean for practice?
Inosin pranobex, as an antiviral drug that modulates cellular and humoral immunity, is used in the treatment of many viral infections. It is employed in diseases caused by herpetic viruses, Epstein-Barr virus (EBV), cytomegalovirus, or in immunodeficient states, especially in cases of cellular immunity disorders. What insights has clinical research offered on this matter?
News Biochemotherapy of Aggressive Rectal Carcinoma – A Case Study from the Czech Republic
Colorectal cancer arises from a complex interplay of environmental and lifestyle factors complemented by hereditary factors. Nowadays, it represents not only a health concern but also a socioeconomic problem. It is the second most common malignant tumor in both sexes; fortunately, its incidence and mortality have been decreasing in recent years. Due to expanding and more accurately targeted treatment options and good patient care management, it is also possible to better manage more aggressive and previously difficult-to-treat forms of the disease, as demonstrated by the following case study from the Comprehensive Cancer Center of the University Hospital Hradec Králové.
News Severe Polytrauma in a Man with von Willebrand Disease − Case Report
The authors of a recently published case report present a case of multiple trauma (including brain injury) in a young man with von Willebrand disease (vWD) type 2A, in whom repeated administration of a concentrate containing von Willebrand factor (vWF) and coagulation factor VIII (FVIII) led to successful healing without neurological deficit.
News How Do Sleep and Depression Influence Each Other?
It is known that most patients with depression encounter some form of sleep disorder. In the following text, we briefly explore the complex relationship between depression and sleep and offer some practical recommendations that can help patients improve their sleep.
News Glucagon for Intranasal Application Newly Available Also in the Czech Republic
Intramuscular administration of glucagon was until recently the only option for acute treatment of hypoglycemia with impaired consciousness at home. However, since July this year, the Baqsimi product – glucagon for intranasal application – is newly available in the Czech Republic.
News Three times on the topic of therapeutic cannabis usage possibilities – case studies from Czech practice
The following case studies from real Czech practice describe three cases of patients with various diagnoses, indicated for cannabis extract administration. In the first case, there was significant pain relief in an elderly patient with vertebrogenic pain syndrome. The second case study outlines the possibilities of using cannabis extract in the treatment of neuropathic pain in a polymorbid elderly patient. The final contribution describes the effect of this preparation in palliative therapy of an oncological patient.
News Anabolic Antiosteoporotic Treatment as a First Step in Patients with Very High Fracture Risk
According to the 2022 opinion of the ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases) working group, it is advisable to identify patients with osteoporosis who have a very high risk of fracture and to use an anabolic antiosteoporotic drug as the initial pharmacotherapeutic intervention, followed by necessary antiresorptive treatment to be addressed over the entire expected length of life.
News Use of Bilastine in Pediatrics − Pathway to Improving Concentration and Performance of Young Allergy Sufferers
In the treatment of allergic diseases, especially in children, safety, good tolerability, simple dosing regimen, and non-sedative effects are the basic requirements for administered medications. Sedative side effects of treatment have a negative impact on sleep patterns and subsequently on children's performance in school. European professional societies recommend the use of modern second-generation antihistamines in the treatment of children. Studies confirm that bilastine, which meets these requirements, should be among the first-choice drugs.
News Sequential Treatment of Schizophrenia – Interactive Case Study
Sequential treatment of schizophrenia helps psychiatrists clarify the stage of the patient's treatment and how to further guide pharmacotherapy. The following case study illustrates the possibilities for reducing negative and cognitive symptoms of schizophrenia while adhering to a metabolically sparing treatment approach.
News How Gut Microbiota Affects Thyroid Function
The composition of gut microbiota has a significant impact on the human body. Studies conducted so far have found a correlation between dysbiosis and a range of diseases, including thyroid disorders (primarily autoimmune, but also the occurrence of nodules or thyroid cancer).
News Current Indications for Negative Pressure Therapy in Wound Healing in Orthopedic and Traumatological Patients
Negative pressure wound therapy was introduced in North America in 1997. Since then, the method has gained great popularity and is used in the treatment of many acute and chronic wounds. Like any other treatment modality, it has its proper indications and contraindications. An overview article by French authors evaluates the current use of negative pressure therapy in the fields of orthopedics and trauma of the musculoskeletal system.
News Metamizole in Pain Therapy in the General Practitioner and Pediatric Office
Metamizole is a pyrazole analgesic-antipyretic with spasmolytic effects, indicated for the treatment of post-traumatic or postoperative pain, visceral colic, cancer pain, and high fever unresponsive to other treatments. The advantage of this drug is its good tolerance without serious adverse effects on the gastrointestinal system, no impact on platelet aggregation, and usability in adults and children of all ages.
News What Benefits Does the Fixed Combination of Candesartan/Amlodipine Bring?
A relatively new fixed combination used in the treatment of hypertension is represented by candesartan/amlodipine, that is, a sartan and a calcium channel blocker. Its advantage compared to the combination of ACE inhibitor/calcium channel blocker is primarily the lower occurrence of side effects.