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News Metformin −⁠ A Proven Helper That Effectively Protects the Heart of Diabetics

Metformin is one of the first-line medications for patients with type 2 diabetes. In addition to lowering blood glucose levels, it also affects other metabolic processes in the human body. Its antitumor, neuroprotective, and especially cardioprotective effects have been extensively studied, which can be advantageously utilized in the diabetic population.

Source: Modern Treatment of Diabetes 19. 10. 2020

News Empagliflozin Secures Reimbursement for Heart Failure Treatment

Starting May 1st, health insurance companies will cover Jardiance^® (empagliflozin) for patients with heart failure with reduced ejection fraction. Cardiologists, pediatric cardiologists, angiologists, and internists will be able to prescribe it with reimbursement. This decision was made by the State Institute for Drug Control (SÚKL) in mid-April. Hundreds of thousands of Czechs suffering from this serious condition will now have access to another effective medication. The drug is manufactured by Boehringer Ingelheim.

Source: Heart Failure 3. 5. 2022

Články časopisu Diabetes mellitus and heart failure: the role of SGLT2 inhibitors

Author of the article: Jindřich Špinar, Jiří Vítovec, Lenka Špinarová Source: Athero Review | 1/2018 7. 3. 2018

News Even a Single Epileptic Seizure is Too Much

Focal epileptic seizures resistant to pharmacotherapy represent an ongoing unmet medical need.

Source: Epilepsy 7. 4. 2022

News Colours of Sepsis 2023: Antimicrobial Stewardship is a Necessity. The Spectrum of Effective Antimicrobial Modalities has Expanded to Include Another Combination

Inappropriate antibiotic (ATB) treatment is associated with high mortality, while unrestricted use of broad-spectrum antibiotics drives resistance development. Thus, the decision to deploy antibiotics becomes a choice between the current and future patient. Antimicrobial stewardship (AMS) is an essential strategy in daily operations. Extending the spectrum of antimicrobial agents is equally crucial in combatting resistant bacterial strains. A symposium on this theme was part of the expert program at this year's 'festival of intensive medicine' Colours of Sepsis, held in late January in Ostrava.

Source: Anti-Infectives 9. 2. 2023

News Prim. Václava Adámková: People mistakenly believe that there are enough antibiotics and that they will always handle infections

According to the World Health Organization (WHO), by 2050, infections untreatable with antibiotics could become the leading cause of death, surpassing cardiovascular and oncological diseases. Rising antimicrobial resistance was one of the main topics at the VIII Congress of Clinical Microbiology, Infectious Diseases, and Epidemiology (KMINE 2022), held in September in Prague. The topic was also the focus of the expert block ‘ATB stewardship,’ where epidemiologist Petr Smejkal, infectologist Aleš Chrdle, and microbiologist Václava Adámková discussed possible solutions to this global problem. We asked Adámková to summarize insights into the presented issues for us.

Source: Anti-Infectives 26. 10. 2022

News Invasive Pneumococcal Disease –⁠ Current Czech Data

The number of reported cases of invasive pneumococcal disease (IPD) returned to levels comparable to those before the COVID-19 pandemic in 2022. Regarding age-specific morbidity, the most at-risk groups are children under 1 year of age and seniors over 65 years old. The specific data for 2022 is provided by a report from the Center for Epidemiology and Microbiology of the National Institute of Public Health (SZÚ).

Source: Regular Vaccination 2. 10. 2023

Články časopisu Vitamin D and cardiovascular diseases

Author of the article: H. Matějovská Kubešová, B. Vepřeková, P. Weber, K. Bielaková, T. Gregorová Source: Kardiologická revue – Interní medicína | 1/2012 9. 3. 2012

News Trastuzumab Deruxtecan in Patients with HER2+ Metastatic Breast Cancer

Last year, results of studies published in the Lancet journal demonstrated a significant clinical benefit of trastuzumab deruxtecan in patients with HER2⁺ metastatic breast cancer (mBC) pre-treated with anti-HER2 therapy, in the 2nd or later lines of treatment compared to trastuzumab emtansine (DESTINY-Breast03 study, second interim overall survival analysis) and after failure of trastuzumab emtansine compared to physician's choice of therapy (DESTINY-Breast02 study).

Source: Ovarian and Breast Cancer 12. 3. 2024

News Treatment of Diabetes in Pregnancy with Metformin Does Not Increase the Risk of Low Birth Weight

In several studies, it has been observed that exposure to metformin during pregnancy, compared to insulin exposure, is associated with an increased relative risk of the newborn being small for gestational age. The authors of the presented cohort study aimed to clarify this risk in comparison to women with gestational diabetes who were not pharmacologically treated.

Source: Modern Treatment of Diabetes 21. 2. 2023

News Eletriptan as an effective and safe drug in acute migraine therapy

In the pharmacotherapy of acute migraine attacks, a pharmacologically diverse group of triptans is particularly used. The choice of the right antimigraine drug should be individualized, based on the intersection of the patient's nature of complaints and the pharmacological profile of the drug. The following text briefly summarizes the basic characteristics and profile of eletriptan.

Source: Treatment of Severe Migraine 20. 9. 2021

News Satisfaction of Patients Treated with Platinum Derivatives with Antiemetic Therapy

The fixed oral combination of netupitant with palonosetron (NEPA) is used for the prevention of nausea and vomiting induced by cytotoxic chemotherapy. A prospective German study evaluated the benefit of this therapy on the quality of life of patients treated with platinum derivatives.

Source: Antiemetic Therapy 23. 9. 2020

News Sequential Treatment of Schizophrenia –⁠ Interactive Case Study

Sequential treatment of schizophrenia helps psychiatrists clarify the stage of the patient's treatment and how to further guide pharmacotherapy. The following case study illustrates the possibilities for reducing negative and cognitive symptoms of schizophrenia while adhering to a metabolically sparing treatment approach.

Source: Modern Treatment of Schizophrenia 14. 9. 2023

News Treatment for Transthyretin Cardiac Amyloidosis is Now More Accessible to Czech Patients

Transthyretin cardiac amyloidosis is a serious progressive disease that was until recently considered untreatable. In recent years, however, new treatment options targeting the underlying pathology of the disease have emerged, which, along with advances in non-invasive diagnostics, offer patients hope for a longer and better-quality life.

Source: Amyloidosis 15. 6. 2023

News New Hematological Biomarker for Early Diagnosis of Sepsis

Sepsis is one of the leading causes of mortality and healthcare expenditure worldwide. Early diagnosis and treatment of septic conditions improve patient prognosis. However, the initial symptoms of sepsis can be difficult to distinguish from other acute conditions due to similar symptomatology. The results of the study presented below indicate that a new hematological biomarker has the potential to facilitate the early diagnosis of sepsis.

Source: Because 13. 9. 2021