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News Probiotics as a Means to Reduce the Incidence of Streptococcus Mutans
Data from a prospective study examining the effects of probiotics on the oral microbiome show the ability of orally administered probiotics to reduce the incidence of Streptococcus mutans and also positively affect the presence of lactobacilli in the oral cavity.
News Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract
Brazilian authors published a review of available information on the mechanism of action of metamizole, its impact on gastrointestinal tract motility, its effect on the gastric mucosa, and its antispasmodic effects.
News Subclinical Hypothyroidism in Pregnancy: How Great Are the Real Risks and Can They Be Effectively Reduced?
The aim of the meta-analysis by authors from the Mayo Clinic was to describe the impact of subclinical hypothyroidism on the course of pregnancy and the effect of levothyroxine replacement therapy in reducing the risk of possible complications.
News Doc. Jiří Kubeš: The major benefit of proton therapy lies in protecting healthy tissues
Nearly 9,000 patients with oncological diseases have already undergone modern proton radiotherapy at the Proton Center in Prague. Which diagnoses are suitable for this treatment modality, what are its main benefits, and what is its place in the comprehensive therapy of malignant tumors? We discuss these topics with the chief physician of this medical facility, Doc. MUDr. Jiří Kubeš, Ph.D.
News Trazodone as an Effective Medicine in the Therapy of Depression and Insomnia
Trazodone (Trittico®) is a medicine indicated for the treatment of depression, which has also been shown to have a positive effect in treating other associated conditions. In practice, however, the potential of its multimodal effect sometimes remains untapped.
News Current Treatment Options for Refractory/Relapsed CLL
How have treatment protocols for chronic lymphocytic leukemia changed in recent years? A review published in Acta Haematologica discusses the current therapeutic options for relapsed or refractory disease.
News Memantine Eases Daily Life for Patients and Caregivers
What is the efficacy and safety of memantine in patients with Alzheimer's disease in routine practice in the Czech Republic? And to what extent can it ease the burden on caregivers of these patients?
News Venotonics in Hemorrhoid Therapy – Results of a Systematic Review
Hemorrhoids are among the most common pathological findings in the anorectal area, and their incidence increases with age. Various modalities are used in the treatment of this condition, which has unpleasant health and psychological complications, aiming to alleviate the symptoms. Widely used and very popular are so-called venotonics, a large group of drugs and dietary supplements, mostly of natural origin, including diosmin.
News INFOGRAPHIC: LDL Cholesterol - Recommended Target Values
Elevated levels of LDL cholesterol are a significant risk factor for cardiovascular diseases, which remain the most common cause of death among adult Czechs. We have strong evidence about who and how LDL-c should be reduced, and ample treatment options to achieve this. Yet, more than half of the patients do not achieve the target LDL-c values. A useful tool for practice can be the 'risk traffic light' - an infographic clearly showing which risk category a patient falls into and what the recommended target LDL-c values are for each risk category. This makes it easier to plan tailor-made individual treatment.
News Dosing of Enoxaparin in Morbidly Obese Patients
How to optimally dose enoxaparin in morbidly obese patients? This question was addressed by a randomized study, the results of which were published in the journal Annals of Pharmacotherapy.
News Benefit of a single intra-articular injection of hyaluronic acid in the treatment of osteoarthritis
Viscosupplementation serves as a minimally invasive procedure to restore the rheological properties of synovial fluid and alleviate pain in patients with symptomatic osteoarthritis (OA). We now have a new 3rd generation hyaluronic acid (HA) product for intra-articular injections – Hyruan One, which uses HA cross-linking technology. The following text summarizes its benefits in the pharmacological management of OA.
News Efficacy and Safety of Single-Application Hyaluronic Acid in Osteoarthritis Therapy
Causal therapy for osteoarthritis does not yet exist. Patients suffering from progressive joint disease are thus dependent on symptomatic medications that alleviate symptoms and partially slow the progression of osteoarthritis. An essential role in therapy is played by viscosupplementation in the form of intra-articular application of hyaluronic acid (HA). Currently, 3rd generation preparations intended for single application are preferred due to their efficiency and safety.
News Pregabalin in the Hands of a General Practitioner
A recent Cochrane systematic review by authors from Oxford University examined the effect of pregabalin in the treatment of postherpetic neuralgia and diabetic neuropathy – conditions that general practitioners frequently encounter in their practice. Is pregabalin a suitable choice in these indications?