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News How can inosine pranobex help with viral infections?

Inosine pranobex has long been used for its immunomodulatory and antiviral effects in the prophylaxis and therapy of various viral infections. Below we summarize its mechanism of action, indications, usage, and side effects.

Source: Viral infections 16. 2. 2023

Články časopisu Neuropsychiatric symptoms as early manifestation of Alzheimer’s disease

Author of the article: V. Matušková, T. Nikolai, H. Marková, K. Čechová, J. Laczó, J. Hort, M. Vyhnálek Source: Česká a slovenská neurologie a neurochirurgie | 1/2020 5. 2. 2020

News Gut-Brain Axis −⁠ Future of MS Treatment?

The relationship between the gut microbiome and multiple sclerosis has been a major topic recently. How far has current science progressed in decoding this issue? A recent review article published in the journal Neuroscience Research summarizes the existing findings on the relationship of the gut microbiome to the etiopathogenesis and course of multiple sclerosis (MS).

Source: Multiple Sclerosis 3. 5. 2022

News Mavacamten in the Treatment of HCM in Patients Referred for Septal Reduction

Extended 56-week follow-up of patients with hypertrophic cardiomyopathy (HCM) resistant to current pharmacotherapy in the VALOR-HCM study confirmed the lasting benefit of mavacamten –⁠ the first representative of a new class of selective reversible cardiac myosin inhibitors –⁠ as a new pharmacological treatment option reducing the need for invasive procedures.

Source: Hypertrophic Cardiomyopathy (HCM) 19. 2. 2024

News Telmisartan –⁠ antihypertensive with cardioprotective effects

Sartans are potent inhibitors of the AT1 receptor for angiotensin II widely used in the therapy of arterial hypertension. Given that chronic activation of the renin-angiotensin-aldosterone system (RAAS) plays an important role not only in the pathogenesis of arterial hypertension but also in the pathogenesis of atherosclerosis and the development of other cardiovascular diseases, the question arises whether the administration of sartans is associated with a broader cardioprotective effect. Telmisartan is the first representative of this group of antihypertensives for which a positive cardioprotective effect has been demonstrated.

Source: Sartans in the Treatment of Hypertension 24. 3. 2022

News Patient Evaluation of Durvalumab Treatment Results

The interim analysis results of the PACIFIC study, which monitored the efficacy of durvalumab in the treatment of locally advanced unresectable non-small cell lung cancer (NSCLC), demonstrated a significantly longer progression-free survival (PFS) with this treatment compared to placebo. The following work analyzed one of the secondary objectives of the PACIFIC study −⁠ patient-reported outcomes (PRO).

Source: Lung Cancer 31. 3. 2020

News Pilot Program for Lung Cancer Screening in the Czech Republic –⁠ Current Interim Results

Since January 1, 2022, a pilot population program for lung cancer screening has been underway in the Czech Republic. At the 7th PREVON conference in December 2023, updates on the progress as of March 31, 2023, were presented. Data for 2022 show a 4.4% detection rate of positive findings using low-dose CT in the targeted population of current or former smokers aged 55-74 years, who have so far undergone screening.

Source: Small Cell Lung Cancer 22. 4. 2024

News How Do Sleep and Depression Influence Each Other?

It is known that most patients with depression encounter some form of sleep disorder. In the following text, we briefly explore the complex relationship between depression and sleep and offer some practical recommendations that can help patients improve their sleep.

Source: Depression and Anxiety 27. 10. 2021

Články časopisu Adult-onset Still’s disease –⁠ a difficult path to diagnosis through fever and effusions of unknown origin

Author of the article: Jana Malegová, Lukáš Koten, Pavel Horák Source: Vnitřní lékařství | 5-6/2014 28. 6. 2014

News Diabetic Retinopathy: A Blind Diabetic as Proof of Serious Neglect of Prevention

Diabetic retinopathy is the most common cause of blindness in working-age patients in developed countries. Early detection of diabetic retinopathy offers a chance to preserve vision. Therefore, careful screening and timely initiation of treatment are crucial.

Source: Diabetes 1. 3. 2021

Články časopisu Definition of sepsis and septic shock

Author of the article: M. Holub Source: Klinická biochemie a metabolismus | 2/2018 10. 4. 2018

Články časopisu Role of prebioptic and bioptic methodsin the screening and diagnosis of cervical cancer

Author of the article: V. Dvořák, R. Pilka Source: Česká gynekologie | 2/2014 21. 4. 2014

Články časopisu Experience with the prostate health index in daily clinical practice

Author of the article: Vojtěch Fiala, Roman Sobotka, Zuzana Vaľová, Michal Pešl, Tomáš Hradec, Tomáš Hanuš, Otakar Čapoun Source: Česká urologie | 4/2017 7. 12. 2017

News Treatment of Schizophrenia in Light of New Findings

"Mental disorders constitute a significant burden on society," began Assoc. Prof. MUDr. Martin Anders, Ph.D., head of the Psychiatric Clinic at the First Faculty of Medicine, Charles University and General University Hospital in Prague, during his presentation at the psychiatric symposium titled "A Chance for a Better Life with Schizophrenia Diagnosis," held on October 18, 2021, in Prague. His lecture focused on key issues in the treatment of schizophrenia, as well as on one of the recently registered antipsychotics—lurasidone.

Source: Modern Treatment of Schizophrenia 14. 12. 2021

News ITP from the Patients' Perspective: How It Affects Their Lives and Which Needs They Find Unmet?

In recent years, new therapeutic options for immune thrombocytopenia (ITP) have been introduced, which are effective for many patients and have significantly improved their quality of life. However, it remains crucial to listen to patients' experiences with treatment and any unmet needs they may have. A meeting of the Platelet Disorder Support Association brought forth many interesting findings and shared experiences. So what troubles ITP patients the most?

Source: Immune Thrombocytopenia 28. 11. 2022