Search results: (10000)
News Etiology and Therapy of Dry Eye Syndrome in a Nutshell
Dry eye syndrome, the most common diagnosis in outpatient ophthalmology practice, is a multifactorial disease with varying severity of symptoms. It reduces the quality of life and can also affect the patient's visual functions. Therapy is individualized according to the primary trigger of the disease and aims to restore the homeostasis of the ocular surface and tear film. Due to the rapid pace of modernization associated with numerous extrinsic factors contributing to the development of dry eye syndrome, its incidence is rising, as well as the number of topical therapeutic options.
News What Next for Patients with CLL After Stopping Venetoclax?
Standard care for untreated patients with chronic lymphocytic leukemia (CLL) is therapy based on venetoclax. However, managing further treatment when venetoclax needs to be discontinued remains a relatively unexplored area without standardized protocols.
News Combination of Targeted Therapy with Chemo in 1st Line in Patients with Left-Sided wtRAS mCRC
The preferred targeted therapy added to the combination with standard chemotherapy (CHT) for left-sided metastatic colorectal cancer (mCRC) with non-mutated RAS oncogene should be an antibody against the epidermal growth factor receptor (anti-EGFR), not against the vascular endothelial growth factor (anti-VEGF). This is based on a direct comparison of anti-EGFR panitumumab and anti-VEGF bevacizumab in the Japanese phase III PARADIGM study. The results were presented at the ASCO 2022 annual meeting.
News How to Dose Beta-Blockers After Myocardial Infarction?
In patients after myocardial infarction (MI), there is a frequent administration of too low doses of beta-blockers (BB) and rare upward titration of their dose after discharge from the hospital. The SWEDEHEART study investigated to what extent the BB dose actually affects 5-year cardiovascular (CV) outcomes, and data from the American registry allowed a focus on mortality after MI depending on BB dosing.
News MD Šimon Kozák: In algology, nothing works miraculously overnight! It is important to seek advice from specialists
Why is it not advisable to rely on one method in pain treatment? What about patients with a mixed type of pain, whose numbers are increasing? And why shouldn’t surgical solutions for back pain be the method of first choice? We discuss all this and other important, current, and practical insights in the field of algology with the head of the pain treatment team at the Clinic of Anesthesiology and Resuscitation of the 3rd Faculty of Medicine, Charles University in Prague, and the University Hospital Královské Vinohrady, MD Šimon Kozák.
News Comparison of Efficacy of Bisoprolol and Metoprolol ZOK in Patients with Mild to Moderate Hypertension – Results of the CREATIVE Study
Suppression of increased activity in the sympathoadrenal system is currently one of the main goals of antihypertensive therapy. Beta-blockers play an important role in regulating the sympathetic nervous system. The CREATIVE study evaluated the efficacy of bisoprolol and metoprolol ZOK on blood pressure and heart rate in patients with mild to moderate primary arterial hypertension.
News Effectiveness of Bisoprolol in Patients with Cardiac Arrhythmias – A Systematic Review of Studies
Last year, a Franco-Romanian team published a study that conducted a systematic review of existing evidence on bisoprolol in the context of arrhythmia treatment. The authors noted that bisoprolol, like other beta-blockers (BB), is used for a variety of cardiovascular diseases, but it is not mentioned in the European Society of Cardiology (ESC) guidelines for managing patients with ventricular arrhythmias and preventing sudden cardiac death.
News Effect of Nuclear Magnetic Resonance Therapy in Patients with Osteoarthritis
Osteoarthritis represents the most common joint disease in adults, with its incidence and prevalence increasing with age. With the overall aging of the population, it is becoming a significant medical as well as social problem. Due to the growing number of cases, new modalities are being sought for current therapeutic procedures, including nuclear magnetic resonance therapy, whose effect has been verified by an extensive clinical study.
News Noonan's Syndrome – History and Present
The genetically determined syndrome linking congenital heart defect with a typical facial phenotype is named after Jacqueline Noonan, a pediatric cardiologist who practiced in the second half of the 20th century. She was the first to recognize and describe it. In the following text, we will briefly introduce it and discuss the circumstances of its discovery.
News Change in Release of Medication Pradaxa
Dear Doctor,
We would like to inform you that from April 1, 2021, based on the decision of the State Institute for Drug Control (SÚKL), the release of the medication (LP) Pradaxa (dabigatran-etexilate) 150 and 110 mg in the indication “Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation” will be changed to first-line treatment.
We would like to inform you that from April 1, 2021, based on the decision of the State Institute for Drug Control (SÚKL), the release of the medication (LP) Pradaxa (dabigatran-etexilate) 150 and 110 mg in the indication “Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation” will be changed to first-line treatment.
News FOLFOXIRI and Panitumumab in mCRC Treatment – Improvement in Treatment Response and Metastasis Resectability
For patients with metastatic colorectal cancer (mCRC) who are able to undergo intensive treatment, the FOLFOX (5-fluorouracil/leucovorin, oxaliplatin) or FOLFIRI (5-fluorouracil/leucovorin, irinotecan) regimens combined with monoclonal antibodies represent the standard first-line treatment. The FOLFOXIRI regimen, which is another option, was developed to further enhance the efficacy of chemotherapy. The German oncologists' VOLFI study investigated the effectiveness of combining targeted therapy and triplet chemotherapy compared to chemotherapy alone in previously untreated patients with mCRC without RAS oncogene mutation.
News How to Save a Leg from Amputation?
Feared complications in diabetics include defects in typical locations on the lower limbs. Their presence and frequent recurrences increase the risk of possible amputation of varying degrees, mainly depending on the involvement of deep structures, i.e., tendons, joint capsules, joints, and bones. How can this scenario be avoided? One answer might be HydroTherapy.
News Possible Uses of Desodrop in Therapy and Prevention of Ophthalmological Diseases
The medical device Desodrop is the first topical eye preparation based on ozone, intended for the prevention and therapy of eye infections and other diseases. Its efficacy and safety have been demonstrated through numerous experimental studies and clinical trials, making it a suitable alternative for topical therapy in children and adults.
News CYP Enzyme? Cytochrome P450 2D6 and Drug Metabolism
The CYP2D6 isoenzyme of cytochrome P450 participates in the metabolism of approximately 20% of commonly used drugs. Genetic variants of this enzyme are very common, leading to significant inter-individual variability in drug metabolism rates. Let’s take a closer look at one of the reasons why the same drug may work very well in one patient, not at all in another, and may cause serious side effects in a third.
News Prof. Martina Koziar Vašáková: In the spotlight of pulmonologists are now lung screening and chronic lung diseases
As part of a series of interviews with the heads of professional societies on the topic of hot topics 2023, we speak with the chairwoman of the Czech Pneumological and Phthiseological Society of the CLS JEP Prof. MUDr. Martina Koziar Vašáková, Ph.D.