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News Meta-analysis of the Effectiveness of Romosozumab in the Treatment of Postmenopausal Osteoporosis

Osteoporosis is a prevalent disease with unmet therapeutic needs. Whether the anti-sclerostin antibody romosozumab can offer an effective improvement in osteoporosis treatment outcomes in postmenopausal women was the central question addressed by the meta-analysis presented below.

Source: Osteoporosis – Trends in Sequential Therapy 29. 2. 2024

News Evaluation of Various VWF Concentrates Regarding Their Ability to Mediate Platelet Binding to Collagen

The study by London researchers on various VWF concentrates focused, among other things, on evaluating their ability to mediate platelet binding to collagen.

Source: Von Willebrand Disease 27. 8. 2020

Články časopisu Serum level of hyaluronic acid –⁠ a marker with a predictive value for radiographic progression of hand osteoarthritis

Author of the article: M. Filková, L. Šenolt, M. Braun, H. Hulejová, A. Pavelková, O. Šléglová, K. Kupka, J. Gatterová, K. Pavelka Source: Česká revmatologie | 4/2009 14. 11. 2009

News Parenteral Nutrition in Oncological Patients in Current ESPEN Recommendations

The current guidelines of the European Society for Clinical Nutrition and Metabolism (ESPEN) address nutritional care in oncological patients −⁠ current knowledge is summarized in a total of 43 recommendations, from which we select some key points, focusing primarily on parenteral nutrition in these patients.

Source: Parenteral Nutrition 15. 3. 2022

Články časopisu Management of convulsive status epilepticus in children

Author of the article: Š. Aulická, P. Aulický, K. Česká, K. Španělová, H. Ošlejšková Source: Anesteziologie a intenzivní medicína | 3/2018 14. 7. 2018

News First Experiences with the Combination of Levodopa/Entacapone/Carbidopa in Intestinal Gel from the Perspective of Patients with Parkinson's Disease

The work presented at the 8th Congress of the European Academy of Neurology (EAN) in Vienna in June 2022 summarizes the first experiences with the use of intestinal gel combining the active ingredients levodopa/entacapone/carbidopa in patients with Parkinson’s disease (PD) in clinical practice in Austria.

Source: Parkinson's Disease 22. 11. 2022

News Evaluation of Joint Condition in Daily Practice in the Era of New Hemophilia Treatment

With the development of new treatment options for hemophilia, there has also been progress in methods for monitoring hemophilic arthropathy and identifying it in its early stages. In addition to classical X-rays, clinical scoring systems, and the gold standard of magnetic resonance imaging (MRI), the so-called POCUS –⁠ point-of-care ultrasound –⁠ has emerged as a quick and reliable method for assessing joint health. Potential biomarkers for osteochondral damage and synovial proliferation specific to hemophilia or for detecting joint bleeding are also being investigated, though their routine use is not anticipated in the near future.

Source: Hemophilia 10. 6. 2024

News Anticoagulation Therapy in Patients on ECMO During the COVID-19 Pandemic

In the past 2 years, the use of extracorporeal membrane oxygenation (ECMO) in intensive care units (ICU) has increased in connection with the treatment of severe COVID-19 pneumonia. Dr. Pilar Marcos Neira from the ICU at Germans Trias i Pujol Hospital in Barcelona has compiled a summary of updated knowledge on anticoagulation therapy in these patients.

Source: Life-threatening Bleeding 8. 4. 2022

News Can We Reach Brain Metastases of Lung Cancer with Anti-EGFR Targeted Therapy?

Information on the penetration of epidermal growth factor receptor tyrosine kinase inhibitors (anti-EGFR TKIs) through the blood-brain barrier primarily comes from preclinical testing. In clinical studies, its effectiveness in patients with brain metastases can be an indicator of its penetration. However, a truly robust analysis is lacking. Until one is available, we can preliminarily evaluate the available data.

Source: Lung Cancer 11. 1. 2021

Články časopisu Actual role of allogeneic haematopoietic transplantation in the treatment of acute myeloid leukaemia

Author of the article: J. Vydra, Z. Ráčil, A. Vítek, P. Cetkovský Source: Transfuze a hematologie dnes | 4/2020 30. 11. 2020

News Correct Selection of Appropriate Incontinence Aid is Crucial for Addressing Patient's Difficulties

Urinary incontinence is an uncomfortable issue that can be resolved by choosing the right incontinence aids. Selecting a quality product is most important for the patient −⁠ it affects their comfort and mental well-being, but choosing the right aid can also be complicated for doctors. The market offers many products of different brands and qualities, where the absorption capacity is often the main selection criteria. However, other important aspects must also be considered.

Source: Incontinence 12. 5. 2022

News According to which parameters can we best assess the quality of incontinence aids?

Properly chosen incontinence aid significantly influences the user's quality of life. When selecting incontinence aids, it is very important to consider their individual properties and parameters. While in European countries the absorbency of the aid is mainly assessed alongside the product's size and the user's gender, other parameters are evaluated elsewhere in the world. So what should we primarily focus on when choosing an aid?

Source: Incontinence 12. 5. 2022

Články časopisu (-2)proPSA and Prostate Health Index (PHI) in predicting the presence of prostate cancer in transrectal biopsies

Author of the article: Kateřina Ryšánková, Vladimír Bartoš, Jan Krhut, Tereza Albínová, Kristián Šafarčík, Ondřej Havránek, Radoslava Tomanová Source: Česká urologie | 1/2018 1. 6. 2018

News Current Results of Brigatinib in the Treatment of Lung Cancer

The results of the primary analysis showed a significant extension of PFS in patients with non-small cell lung cancer (NSCLC) treated with brigatinib compared to crizotinib. The recently published secondary analysis confirms these results.

Source: Non-Small Cell Lung Cancer 4. 6. 2021

News Fatigue in Multiple Sclerosis: What Can Teriflunomide Do?

An article by French authors published in January this year in the journal Multiple Sclerosis and Related Disorders evaluated the effect of teriflunomide on fatigue in patients with multiple sclerosis in real-world practice.

Source: Multiple Sclerosis 19. 4. 2021