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News Efficacy and Tolerance of Dorzolamide/Timolol Combination With and Without Preservatives in Patients With Elevated Intraocular Pressure

The fixed combination of the carbonic anhydrase inhibitor dorzolamide and the locally acting beta-blocker timolol is indicated for the treatment of elevated intraocular pressure in patients with open-angle glaucoma. The comparison of the efficacy and tolerance of this combination with preservatives, associated among other things with eye irritation, and without them was the subject of the American study presented below.

Source: Treatment of Glaucoma 21. 8. 2020

News Patient Evaluation of Durvalumab Treatment Results

The interim analysis results of the PACIFIC study, which monitored the efficacy of durvalumab in the treatment of locally advanced unresectable non-small cell lung cancer (NSCLC), demonstrated a significantly longer progression-free survival (PFS) with this treatment compared to placebo. The following work analyzed one of the secondary objectives of the PACIFIC study −⁠ patient-reported outcomes (PRO).

Source: Lung Cancer 31. 3. 2020

News EMPATHY Questionnaire as a Tool for Better Personalization of Levothyroxine Doses in Patients with Primary Hypothyroidism?

The therapy for hypothyroidism consists of substitution with levothyroxine (L-T4). Failure to achieve the target thyrotropin hormone (TSH) level can be due to non-compliance (in 60% of cases) or malabsorption of the drug (in 40%). The aim of the presented Italian study was the validation of the EMPATHY questionnaire for better personalization of therapy.

Source: Thyroid Disorders 25. 10. 2022

Články časopisu Immunotherapy in the Treatment of Lung Cancer

Author of the article: O. Fiala, O. Šorejs, M. Pešek, J. Fínek Source: Klinická onkologie | Supplementum3/2017 12. 12. 2017

News Criteria for Progression in Fibrotic Non-IPF Interstitial Lung Disease

Fibrotic interstitial lung disease (fILD) is a challenging condition to manage with limited therapeutic options and a poor prognosis. The currently published review analyzes the criteria for its progression defining the presence of progressive pulmonary fibrosis (PPF), describes their relative prevalence, and prognostic significance.

Source: Progressive Interstitial Pulmonary Processes 11. 12. 2023

News Multiparametric Magnetic Resonance in Predicting Progression of Low-Risk Prostate Cancer

A newly published study has demonstrated the utility of imaging using multiparametric magnetic resonance imaging (mpMRI) and its interpretation using PI-RADS version 2 (Prostate Imaging Reporting and Data System) in predicting unfavorable disease outcomes in patients with prostate cancer suitable for active surveillance.

Source: Prostate Health Index 4. 6. 2020

News Increase in Thyroid Cancer Incidence Due to the Coronavirus Pandemic?

According to available data, COVID-19 disease does not worsen the course of thyroid cancer. However, the restriction of medical care during the pandemic is associated with concern about an increase in the incidence of this malignant disease and the associated morbidity and mortality.

Source: Thyroid Disorders 6. 5. 2021

News Is the combination of tiotropium/olodaterol proven more effective in reducing the risk of clinically significant worsening of COPD compared to monotherapy?

Given the heterogeneity of chronic obstructive pulmonary disease (COPD), the use of a composite parameter that includes lung function, the occurrence of exacerbations, and quality of life offers a more comprehensive view of treatment outcomes. Such a parameter was used in the analysis of the TONADO studies, which compared early use of the fixed combination of tiotropium/olodaterol with tiotropium alone.

Source: COPD 26. 8. 2021

News Dupilumab Improves Skin and Systemic Symptoms of Atopic Dermatitis

A clinical study conducted in the USA and Canada demonstrated the efficacy of dupilumab in treating moderate to severe atopic dermatitis, improving both skin symptoms and suppressing systemic inflammatory markers.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 20. 6. 2022

Články časopisu Use of the KLS Martin Nd:YAG laser MY 40 1.3 in Lung Parenchyma Surgery

Author of the article: J. Vodička, Špidlen V., Klečka J., Šimánek V., Šafránek J. Source: Rozhledy v chirurgii | 5/2009 7. 5. 2009

News Atectura® and Enerzair® from May 1, 2021 with Health Insurance Coverage

The fixed combination of indacaterol acetate (LABA) and mometasone furoate (ICS) Atectura® and the fixed triple combination, which in addition to these two substances also includes glycopyrronium bromide (LAMA), Enerzair® for maintenance inhalation treatment of bronchial asthma, approved in the EU last year, have established health insurance coverage in the Czech Republic from May 1, 2021. We bring a summary of the conditions for reimbursement.

Source: Asthma under control 2. 9. 2021

News Cenobamate in the Therapy of Pharmacoresistant Epilepsy in a Warfarinized Patient –⁠ A Case Study

A case study from Czech practice presents a patient with pharmacoresistant epilepsy and concurrent warfarin medication for heart valve replacement, where the INR value remained within the cardiologist’s recommended range without further adjustments to anticoagulant therapy during combined antiepileptic therapy with cenobamate (CNB) under the recommended dose titration.

Source: Epilepsy 13. 9. 2023

News Efficacy of Conventional and Intensified Lifestyle Interventions in Individuals with Prediabetes According to Risk Level

Lifestyle changes can prevent the development of type 2 diabetes in individuals with prediabetes, but according to current findings, these measures fail for a significant portion of study participants. In the Diabetes Prevention Program (DPP) study, one in five patients in the lifestyle intervention group developed type 2 diabetes within 4 years. However, there are individuals with prediabetes who do not develop diabetes without lifestyle intervention even after 11 years of follow-up. This indicates the need to create more precisely stratified intervention strategies based on the identification of high-risk (HR) and low-risk (LR) individuals with prediabetes. This is precisely the focus of a recently published study by German authors.

Source: Modern Treatment of Diabetes 2. 11. 2022

News Summary of New American Recommendations for Heart Failure Management

This year, the American Heart Association (AHA), the American College of Cardiology (ACC), and the Heart Failure Society of America (HFSA) released joint recommendations for the diagnosis and treatment of heart failure in clinical practice. These new guidelines replace the previous recommendations from 2013 and their 2017 update. We summarize the 10 key points to remember as outlined by the authors of the new guidelines and focus on the treatment of the subgroup of patients with heart failure with preserved ejection fraction (HFpEF).

Source: Heart Failure 28. 6. 2022

Články časopisu Novel molecules used in the targeted treatment of acute myeloid leukaemia –⁠ adverse reactions, treatment complications and signifi cant drug interactions

Author of the article: J. Vedrová, Z. Ráčil Source: Transfuze a hematologie dnes | 1/2021 15. 3. 2021