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News Idiopathic Pulmonary Fibrosis from the Perspective of an Outpatient Pulmonologist
Idiopathic pulmonary fibrosis represents a rare disease of lung tissue with an as-yet-unexplained etiology. In the framework of differential diagnosis, it is necessary to consider the disease, as early diagnosis combined with the deployment of antifibrotic therapy extends patients' lives.
News ESC 2022: Heart Failure with Preserved Ejection Fraction as an Underdiagnosed Problem: How to Increase Its Detection in Everyday Practice?
During this year's European Society of Cardiology Congress (ESC 2022), alarming information was shared, indicating that heart failure with preserved ejection fraction of the left ventricle (HFpEF) is likely underdiagnosed in clinical practice, necessitating improved identification and detection of patients with this condition. One of the symposiums addressed not only the reasons why many patients with HFpEF are misdiagnosed.
News Changes in Intestinal Microflora Correlate with Disease Activity in Patients with Lupus Erythematosus
The role of intestinal microflora in the pathogenesis of autoimmune diseases, including lupus erythematosus, has been discussed for a long time. An American study discovered a specific bacterium whose proliferation in the intestine correlates not only with the occurrence of the disease but also with its activity.
News MS in Children – An Overlooked Sister of Adult Diseases?
Multiple sclerosis is not just an adult disease. How common is it in children and how have current therapeutic possibilities advanced for this population both in our country and around the world?
News Safety and Tolerability of Bilastine in the Treatment of Chronic Urticaria in Children
Chronic urticaria is less common in pediatric patients compared to the acute form, but it always requires therapy due to bothersome chronic symptoms that reduce quality of life and disrupt daily activities of affected children. According to recent guidelines, the first-line treatment is non-sedating second-generation antihistamines, among which bilastine is included.
News Fatigue and Quality of Life in Patients with Primary Biliary Cholangitis
Fatigue is the most common symptom of primary biliary cholangitis (PBC). Its occurrence significantly impacts the health-related quality of life of patients.
News Thanks to Buccolam, the reality of suppressing convulsive seizures in children and adolescents approaches parents' ideal management
What crosses the mind of a parent when they notice their epileptic child or adolescent is having a convulsive seizure? They want it to be over quickly and safely. What constitutes the integral part that makes this wish a reality? And how does the newest treatment modality, buccally administered midazolam (Buccolam), address these needs?
News AAD 2023: Efficacy of Bimekizumab in the Treatment of Hidradenitis Suppurativa
At the latest annual congress of the American Academy of Dermatology (AAD), held March 17-22, 2023 in New Orleans, the results of the phase III BE HEARD I and II studies were presented among late-breaking presentations. The studies demonstrate the safety and high efficacy of bimekizumab in the treatment of adults with moderate to severe hidradenitis suppurativa (HS).
News Expert Consensus on the Use of Bimekizumab in the Treatment of Plaque Psoriasis and Psoriatic Arthritis
The expert consensus published in February 2024 offers guidance on the use of bimekizumab in the treatment of patients with moderate to severe plaque psoriasis and psoriatic arthritis. It is based on a literature review and an assessment of data from 19 relevant studies. A panel of 9 American dermatologists specializing in psoriasis treatment created and adopted 14 consensus statements and recommendations, 12 of which have a strength of “A”.
News Case of Heparin Allergy and Preventive Administration of Fondaparinux in Pregnancy – Case Study
The presented case study discusses a complicated case of a 40-year-old woman with essential thrombocythemia (ET), a history of intrauterine fetal death, and recurrent pulmonary embolism (PE). The patient developed an allergic reaction to low-molecular-weight heparin (LMWH) and was successfully managed with fondaparinux during pregnancy.
News Combined Hormonal Contraception in the Treatment of Dysmenorrhea
Dysmenorrhea troubles many women of reproductive age and can deteriorate their quality of life, making it important for doctors to offer suitable therapy. We summarize the findings of research on the use of hormonal contraception containing drospirenone (DRSP) and ethinylestradiol (EE) in the treatment of dysmenorrhea.
News Comparison of the Effect of Sonic and Manual Toothbrushes on Dental Plaque and Gingivitis Control
A clinical study on healthy volunteers with mild to moderate gingivitis compared the effectiveness of sonic and manual toothbrushes in terms of dental plaque and gingivitis occurrence. The results of the study showed that the sonic toothbrush outperformed the manual one in all observed parameters.
News Negative Symptoms of Schizophrenia and Their Assessment
Schizophrenia is a serious psychiatric disorder with a prevalence of up to 1%. It can manifest with both negative and positive symptoms. We briefly summarize the clinical assessment and rating scales of negative symptoms in the following text.
News FEIBA in Real Clinical Practice – Fresh Data from the Observational Study FEIBA GO
FEIBA GO (Global Outcome) was a prospective observational study evaluating the long-term administration of FEIBA, its safety, efficacy, and quality of life for patients with hemophilia A or B and high-titer inhibitors (high responders), who were receiving aPCC in routine clinical practice. The study, whose results were recently published, was conducted at 25 centers in 11 countries.
News Teriflunomide vs. Dimethyl Fumarate: Does Their Classification into Different Treatment Lines Have Merit?
Teriflunomide is one of the first-choice medications in the treatment of multiple sclerosis (MS) patients, not only in the Czech Republic. Conversely, the use of dimethyl fumarate is more limited here compared to other countries. Did the data from real-world clinical practice published this year actually demonstrate differences in the efficacy of both medications, and thus justify their classification?
News Even a Single Epileptic Seizure is Too Much
Focal epileptic seizures resistant to pharmacotherapy represent an ongoing unmet medical need.
News Adjuvant Treatment of Early Invasive HER2+ Breast Cancer − Results of the Katherine Study
Women with breast cancer found to have residual invasive disease during surgery after neoadjuvant chemotherapy and HER2-targeted therapy have a significantly worse prognosis. For these patients, the Czech Oncology Society ČLS JEP recommends adjuvant therapy with trastuzumab emtansine based on data from the Katherine clinical study. However, this treatment has not yet been covered by public health insurance, with reimbursement starting from March 1, 2021.
News Comparison of Duloxetine, Gabapentin, and Pregabalin in the Treatment of Diabetic Neuropathic Pain
Painful diabetic neuropathy represents an unpleasant complication of diabetes, in which several groups of drugs are used in therapy. Among their representatives are duloxetine, gabapentin, and pregabalin. The meta-analysis, whose conclusions we summarize below, focused on comparing their effectiveness and tolerability.
News Subclinical Hypothyroidism in Pregnancy: How Great Are the Real Risks and Can They Be Effectively Reduced?
The aim of the meta-analysis by authors from the Mayo Clinic was to describe the impact of subclinical hypothyroidism on the course of pregnancy and the effect of levothyroxine replacement therapy in reducing the risk of possible complications.
News Use of Medical Cannabis in Patients with Fibromyalgia to Relieve Pain and Depression
Medical cannabis is prescribed to patients with chronic pain resistant to conventional treatments. The efficacy of tetrahydrocannabinol (THC) therapy in patients with fibromyalgia syndrome (FMS) was recently evaluated in a German study.
News Long-term effect of the triple combination of perindopril, indapamide, and amlodipine on left ventricular hypertrophy in hypertension
A recent open-label interventional study aimed to describe the long-term effect of a fixed triple combination of perindopril, indapamide, and amlodipine compared to a free combination of a RAAS inhibitor, diuretic, and calcium channel blocker on the reduction of left ventricular hypertrophy (LVH) in hypertensive outpatients.
News Effect of 3 Different Doses of Trazodone on QT Interval Length
Patients diagnosed with depression often also suffer from cardiovascular diseases, including heart failure. Given the increased risk of death in such comorbid patients, the safety and efficacy of the antidepressant must be considered when choosing one.
News Fatigue as a Significant Symptom of Immune Thrombocytopenia from the Patients' Perspective
The I-WISh survey assessed the impact of immune thrombocytopenia (ITP) and its treatment on patients' lives. Patients identified fatigue as the most frequent, severe, and persistent symptom associated with ITP, unlike doctors who did not attribute such significance to this symptom. Recently published survey results also showed that patients need support from multiple sources, including doctors, family, friends, and patient groups.
News Bilastine and its role in the treatment of allergic rhinoconjunctivitis and urticaria in children
The prevalence of allergic rhinitis (AR) in the pediatric population is estimated worldwide at 10-20%. The efficacy and safety of bilastine (a second-generation antihistamine) in adult patients and adolescents have already been proven in clinical studies. Below we summarize experiences with its use in children under 12 years of age.