Search results: (10000)
News Eletriptan and Its Role in Acute Migraine Therapy
In the acute treatment of moderate to severe migraine attacks, medications from the triptan group are primarily used. The following article summarizes important findings about eletriptan and its key results in clinical studies.
News Overview of Current Treatment Options for MRSA-Induced Pneumonia
Pneumonia caused by methicillin-resistant strains of Staphylococcus aureus (MRSA) remains a disease with high mortality requiring urgent treatment, whether it is a community-acquired or nosocomial infection. Italian authors published a review article at the beginning of 2022, describing the current available treatment modalities for this infection based on a literature survey.
News Role of Transthyretin in the Development of Amyloidosis
Transthyretin (TTR), one of the transport proteins, tends to form extracellular deposits that accumulate in key organs, such as the heart and nerves. The formation of TTR deposits leads to the development of systemic amyloidosis, a disease with highly heterogeneous clinical manifestations. Warning signs may include carpal tunnel syndrome, among others. What is the physiological role of TTR in the body and what role does its structure play in the development of amyloidosis?
News Frequency of Mutations in Genes Predisposing to Ovarian Cancer in the Czech Population
The authors of a Czech study evaluating the occurrence of mutations in tumor-predisposing genes for ovarian cancer hypothesized that if their occurrence in patients with this diagnosis was significant, identifying carriers of these mutations could help reduce the prevalence and mortality of this disease given the absence of other screening tools.
News Can the Fixed Combination of Tramadol/Acetaminophen Significantly Reduce Back Pain Uncontrolled by NSAIDs?
One way to prevent drug-related complications in the treatment of lower back pain (LBP) while improving patients' functioning in daily activities is the prescription of the weak opioid agonist tramadol in combination with acetaminophen. A smaller Japanese observational study focused on the effectiveness of this treatment in reducing the disability of patients with chronic LBP, improving their daily activities, and the occurrence of adverse events.
News Prof. Martina Koziar Vašáková: In the spotlight of pulmonologists are now lung screening and chronic lung diseases
As part of a series of interviews with the heads of professional societies on the topic of hot topics 2023, we speak with the chairwoman of the Czech Pneumological and Phthiseological Society of the CLS JEP Prof. MUDr. Martina Koziar Vašáková, Ph.D.
News Update of the Blue Book: What's New in the Treatment of Metastatic NSCLC with an ALK Gene Mutation?
As of March 1, 2022, the 28th update of the Blue Book by the Czech Society for Oncology of ČLS JEP was released. Let's take a look at what changes it has brought compared to the previous version in the treatment of metastatic non-small cell lung cancer (NSCLC) with a driver mutation in the ALK gene.
News Itoprid helps diabetics with reduced gastrointestinal motility improve diabetes control
The prokinetic itoprid led not only to the alleviation of gastroparesis symptoms and an improvement in quality of life in a prospective multicenter observational study on patients with diabetes and reduced gastrointestinal (GI) motility, but also to an improvement in glycemic parameters.
News Innovation in Wound Healing: Zetuvit Plus Silicone Border for Optimal Wound Exudate Management
Excessive wound exudate can lead to delayed healing, skin damage around the wound, or leakage under the chosen dressing. Zetuvit Plus Silicone Border dressing with high absorbent and retention capacity offers confidence in treating both chronic and acute wounds and high comfort for the patient.
News Is Dupilumab Effective in AD Therapy for Patients for Whom Cyclosporine A Fails or Cannot Be Given?
Severe forms of atopic dermatitis (AD) may require systemic therapy. However, the immunosuppressant cyclosporine A does not have sufficient efficacy in some patients with AD or is contraindicated for them. Therefore, the phase III clinical trial LIBERTY AD CAFÉ evaluated the efficacy of dupilumab in these patients.
News When to Switch to Second-Line Treatment for Primary Biliary Cholangitis?
In patients with primary biliary cholangitis (PBC), the response to ursodeoxycholic acid (UDCA) treatment is an important prognostic indicator. To identify patients with an insufficient response to this modality who require second-line therapy, the best practice is to assess the biochemical response to UDCA after 12 months of treatment. A validated and easy-to-use tool is the determination of serum alkaline phosphatase (ALP) activity and serum total bilirubin concentration. Although treatment response to UDCA is commonly checked after 12 months, a 6-month check has the same discriminatory value.
News Intestinal Infection of Multi-Resistant NDM-Producing K. pneumoniae in a Patient with NK/T Lymphoma – Case Study
The incidence of NDM-producing Klebsiella pneumoniae is increasing worldwide. NDM beta-lactamase is a significant cause of multidrug resistance in enterobacteria to various antibiotics, including carbapenems. Currently, the most suitable approach for the treatment of intestinal infections caused by NDM-producing K. pneumoniae is considered to be the combination of ceftazidime/avibactam with aztreonam. The following case study also illustrates its use in more complicated cases.
News Impact of Lurasidone on Metabolic Functions Compared to Other Antipsychotics – Results of a Large Meta-Analysis
Antipsychotic therapy is associated with varying degrees of metabolic abnormalities in parameters of weight, lipid metabolism, and glucose metabolism. The presence of metabolic syndrome or isolated disorders of glucose and lipid metabolism further increases the risk of morbidity and mortality in patients with schizophrenia compared to the general population. Lurasidone is an antipsychotic indicated for the acute and maintenance treatment of schizophrenia. The advantage of this drug is its low risk of metabolic side effects, which has been confirmed in a recent large meta-analysis of clinical studies.
News Biochemotherapy of Aggressive Rectal Carcinoma – A Case Study from the Czech Republic
Colorectal cancer arises from a complex interplay of environmental and lifestyle factors complemented by hereditary factors. Nowadays, it represents not only a health concern but also a socioeconomic problem. It is the second most common malignant tumor in both sexes; fortunately, its incidence and mortality have been decreasing in recent years. Due to expanding and more accurately targeted treatment options and good patient care management, it is also possible to better manage more aggressive and previously difficult-to-treat forms of the disease, as demonstrated by the following case study from the Comprehensive Cancer Center of the University Hospital Hradec Králové.
News Impact of Antiemetic Prophylaxis on Quality of Life of Patients Treated with Chemotherapy – Data from Practice
Chemotherapy-induced nausea and vomiting (CINV) is a relatively common complication of cancer treatment with a significantly negative impact on patients' quality of life. A large prospective analysis of real-world clinical practice data was conducted in Germany, examining the efficacy and safety of treatment with the oral combination of netupitant and palonosetron and the impact of this therapy on patients' quality of life.
News Modification of Criteria for Diagnosing Irritable Bowel Syndrome in Clinical Practice
The Rome criteria for diagnosing disorders of gut-brain interaction (DGBI) have recently been modified due to discrepancies with their use in clinical practice. The Rome Foundation board has created modified Rome IV diagnostic criteria. When caring for patients with DGBI, including irritable bowel syndrome (IBS), it will be possible to diagnose even with shorter duration and lower frequency of symptoms.
News Valproate for Acute Mania: Is Practice Really Evidence-Based and Recommended?
Authors from the University of Western Ontario conducted an audit in an acute psychiatric intake unit to determine whether the prescription of valproate there corresponded to evidence-based recommendations.
News To Vaccinate or Not to Vaccinate? That’s the Question for MS and COVID-19
What is the response of patients with multiple sclerosis (MS) to vaccination against COVID-19 considering the type of their treatment? Is there an increased risk of relapse after vaccination? And how to proceed with a particular patient? Although COVID-19 has been a relevant issue for a relatively long time, unfortunately, this topic remains current. Unlike in 2020, however, our knowledge has significantly advanced. Currently, relatively extensive data are available even for specific groups of the population – including precisely MS patients.
News Benefit of a single intra-articular injection of hyaluronic acid in the treatment of osteoarthritis
Viscosupplementation serves as a minimally invasive procedure to restore the rheological properties of synovial fluid and alleviate pain in patients with symptomatic osteoarthritis (OA). We now have a new 3rd generation hyaluronic acid (HA) product for intra-articular injections – Hyruan One, which uses HA cross-linking technology. The following text summarizes its benefits in the pharmacological management of OA.