Genotyping of the Main Histocompatible HLA System for Transplantation of HaematopoieticStem Cells


Authors: M. Dobrovolná;  M. Loudová;  M. Vraná
Authors‘ workplace: Ústav hematologie a krevní transfuze, Praha
Published in: Listy rev. Lék., , 2002, č. 3, s. 0
Category:

Overview

Transplantation of bone marrow or peripheral stem cells is part of the standard protocols in the treatment of haematologicalmalignities and metabolic disorders and immunodeficiencies. From the aspect of compatibility of the donor and recipient ofHCS agreement in five HLA locuses is decisive: HLA-A, B-, C-, DRB1-, DQB1-. The extent of agreement between the patient anddonor in the HLA system which is the most polymorphous genetic system of man is reliably detectable only at the DNA level.Our department assesses the HLA compatibility for the needs of the Institute of Haematology and Blood Transfusion and theSecond Paediatric Clinic of the Motol Faculty Hospital. Every year some 200 subjects are examined.

Key words:
transplantation of haematopoietic stem cells (HSCT) – main histocompatible systemHLA – genotyping of HLA allels

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Labels
Medical assessment Occupational medicine
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