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Metformin and pregnancy


Authors: MUC. Jan Přáda;  MUDr. Kateřina Anderlová, Ph.D.
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN Praha
Published in: Prakt Gyn 2015; 19(1): 74-76
Category: Students Articles: Review Article

Overview

Insulin has always been used a drug of choice in a treatment for pregnant women with diabetes mellitus. On the contrary, metformin and other oral hypoglycemic agents have not been used because of concerns about possible harm caused to the fetus. However, the latest studies prove that the safety of using metformin during pregnancy is equal to insulin therapy and it might even offer certain positives.

Key words:
diabetes mellitus – pregnancy – oral hypoglycemic agents – metformin


Sources

1. Kavitha N, De S, Kanagasabai S. Oral Hypoglycemic Agents in pregnancy: An Update. J Obstet Gynecol India 2013; 63(2): 82–87.

2. Centers for Disease Control and Prevention. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2011. Dostupné z WWW: <http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf>.

3. Gui J, Liu Q, Feng L. Metformin vs Insulin in the Management of Gestational Diabetes: A Meta-Analysis. PLoS One 2013; 8(5): e64585. Dostupné z DOI: <http://doi: 10.1371/journal.pone.0064585>.

4. Eyal S et al. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos 2010; 38(5): 833–840.

5. Rowan JA, Rush EC, Obolonkin V et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU). Body composition at 2 years of age. Diabetes Care 2011; 34(10): 2279–2284.

6. Balani J, Hyer SL, Rodin DA et al. Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case–control study. Diabet Med 2009; 26(8): 798–802

7. Metzger BE, Gabbe SG, Persson B et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010; 33(3): 676–682.

8. Ryu RJ, Hays KE, Hebert MF. Gestational diabetes mellitus management with oral hypoglycemic agents. Semin Perinatol 2014; 38(8): 508–515.

9. Lautatzis ME, Goulis DG, Vrontakis M. Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review. Metabolism 2013; 62(11): 1522–1534.

10. Ali AT, Ferris WF, Naran NH et al. Insulin resistance in the control of body fat distribution: a new hypothesis. Horm Metab Res 2011; 43(2): 77–80.

11. Rowan JA, Hague WM, Gao W et al. MiG Trial Investigators. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 2008, 358(19): 2003–2015

12. Gilligan M. Metformin and vitamin B12 deficiency. Arch Intern Med 2002; 162(4): 484–485 

13. Stang M, Wysowski DK, Butler-Jones D. Incidence of lactic acidosis in metformin users. Diabetes Care 1999, 22(6): 925–927.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Practical Gynecology

Issue 1

2015 Issue 1

Most read in this issue
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