Screening of thyreopathies in pregnancy

Authors: Jan Jiskra;  Zdeňka Límanová
Authors‘ workplace: III. interní klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
Published in: Prakt Gyn 2013; 17(1): 61-67
Category: Gynecology and Obstetrics: Review Article


High prevalence and negative impact of untreated thyroid diseases on the pregnancy arises worldwide discussion about the most effective strategy of their screening. There is general consensus that the screening should be focused on the clinically high-risk women (“aggressive case-finding”) and should include investigation of serum TSH (thyroid stimulatory hormone). However, such restricted screening omits 30-80 % of women with positive laboratory results (at least 50 % of women according to studies performed in Czech Republic). Therefore, in recently published national guidelines Czech Endocrine Society ČSL JEP endorses universal screening which should include investigation of serum TSH and TPOAb (antibodies to thyroid peroxidase) among women in the first trimester of pregnancy.

Key words:
pregnancy – hypothyroidism – thyroid stimulatory hormone – antibodies against thyroid peroxidase – miscarriage


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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