Cefixime in the Treatment of Relapsing and Protracted Sinusitis

Authors: J. Valvoda;  M. Hroboň
Authors‘ workplace: Otorinolaryngologické odd. VFN, Praha
Published in: Otorinolaryng. a Foniat. /Prague/, , 2001, No. 1, pp. 32-37.


The authors describe theire experience with the use of cefixime, an oral cephalosporinof the third generation in relapsing and protracted sinusitis. The group of patients comprised 17adults and five children the majority of which was treated with several antibiotics before cefiximeadministration. The pathogenetic microbial agent was found only in four patients: Klebsiellaoxytoca, Streptococcus pneumoniae and Haemophilus influenzae. In the remainder the cultivationform the punctate was negative or contained a so-called physiological flora - most frequently Str.viridans. In none of the cases Staphylococcus aureus was detected as the etiological agent, whichis resistant to cefixime. The mean period of cefixim treatment was eight days, treatment wassuccessful in 100%. In case of putrid empyemas of the maxillary sinuses and odontogenic sinusitisa combination of cefixim with general and local treatment with metronidazole proved very useful.The assembled findings make it possible to recommend cefixim as an effective antibiotic for thetreatment of refractory or relapsing sinusitis caused by sensitive microorganisms.

Key words:
cefixim, protracted and relapsing sinusitis, bacteriological findings.

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Audiology Paediatric ENT ENT (Otorhinolaryngology)
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