Basal cell carcinoma and the modalities of its therapy

Authors: Petr Arenberger;  Jiří Ettler
Authors‘ workplace: Dermatovenerologická klinika 3. LF UK a FNKV, Praha
Published in: Čas. Lék. čes. 2017; 156: 113-116
Category: Review Article


Basal cell carcinoma (BCC) also known as basalioma or basal cell cancer, is the most common skin cancer. BCC has a very low metastatic risk. This tumor can cause significant disfigurement by invading surrounding tissues. It occurs mainly in fair-skinned patients with a family history of this cancer. Sunlight is a factor in about two-thirds of these cancers. Standard surgical excision is the treatment of choice. Mohs micrographic surgery is an outpatient or inpatient procedure in which the tumor is surgically excised and then immediately examined under a microscope. Cryosurgery is an old modality for the treatment of many skin cancers. Other treatment options incl. photodynamic therapy, topical immunotherapy, radiation or targeted therapy will be discussed.

basal cell carcinoma, surgery, immunotherapy, photodynamic therapy, targeted therapy


1. Bala Subramanyam S, Naga Sujata D, Sridhar K, Pushpanjali M. Nevoid basal cell carcinoma syndrome: a case report and review. J Maxillofac Oral Surg 2015; 14(Suppl. 1): 11–15.

2. Correia de Sá TR, Silva R, Lopes JM. Basal cell carcinoma of the skin (part 2): diagnosis, prognosis and management. Future Oncol 2015; 11(22): 3023–3038.

3. Guenther LC, Barber K, Searles GE et al. Non-melanoma skin cancer in Canada Chapter 1: Introduction to the Guidelines. J Cutan Med Surg 2015; 19(3): 205–215.

4. Chen L, Silapunt S, Migden MR. Sonidegib for the treatment of advanced basal cell carcinoma: a comprehensive review of sonidegib and the BOLT trial with 12-month update. Future Oncol 2016; 12(18): 2095–2105.

5. Kim M, Jung HY, Park HJ. Topical PDT in the treatment of benign skin diseases: Principles and new applications. Int J Mol Sci 2015; 16(10): 23259–23278.

6. Prieto-Granada C, Rodriguez-Waitkus P. Basal cell carcinoma: Epidemiology, clinical and histologic features, and basic science overview. Curr Probl Cancer 2015; 39(4): 198–205.

7. Rimkus TK, Carpenter RL, Qasem S et al. Targeting the Sonic Hedgehog signaling pathway: Review of smoothened and GLI inhibitors. Cancers (Basel) 2016; 8: 22.

8. Savoia P, Cremona O, Fava P. New perspectives in the pharmacological treatment of non-melanoma skin cancer. Curr Drug Targets 2016; 17(3): 353–374.

9. Tan CZ, Rieger KE, Sarin KY. Basosquamous carcinoma: controversy, advances, and future directions. Dermatol Surg 2017; 43(1): 23–31.

10. Xin M. Hedgehog inhibitors: a patent review (2013 – present). Expert Opin Ther Pat 2015; 25(5): 549–565.

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management fenix.admin.empty
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account