Allergen Challenge Used to Diagnose Food Allergy – Oral Allergy Syndrome
Authors:
H. Vávrová; M. Heroldová; P. Kučera
Authors‘ workplace:
Oddělení alergologie a klinické imunologie, Ústav imunologie 3. LF UK a FNKV, Praha
Published in:
Čas. Lék. čes. 2008; 147: 355-359
Category:
Review Article
Overview
Food allergy is an immune mediated unwanted side effect to food. All types of hypersensitivity can be involved; the most prevalent is IgE mediated one. The diagnosis is based on the history, skin tests with allergens and detection of specific IgE. These procedures are not highly predictive for clinical reactivity to food allergens, true clinical reactivity can be confirmed by allergen challenge. Oral allergy syndrome is represented by mostly subjective symptoms in oral cavity, usually triggered by fruit or vegetable allergens, cross-reacting with pollen allergens. This cross-reactivity is based on protein homology and immunologic similarity. To confirm the diagnosis of food allergy, the „golden standard“ is the double blind placebo controlled food challenge. The basic features of this test are discussed, particularly in the diagnosis of the oral allergy syndrome. Controlled food challenge is a useful test for patient’s diagnosis confirmation, evaluation of other diagnostic tests or evaluation of food allergenicity.
Key words:
oral allergy syndrome, food allergen, double blind placebo controlled food challenge.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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