Autoantibodies in the Pathogenesis and Diagnosis of Insulin-dependent Diabetes Mellitus
Authors:
M. Prázný; J. Škrha
Authors‘ workplace:
III. interní klinika 1. LF UK a VFN, Praha
Published in:
Čas. Lék. čes. 1999; : 268-271
Category:
Overview
Insulin-dependent diabetes mellitus is considered an autoimmune disease. The immune response is targeted onautoantigens of B-cells of the islets of Langerhans. The most important autoantigens are glutamic acid decarboxylase,protein tyrosine phosphatase and insulin. Despite the fact that their role in the pathogenesis of insulin-dependentdiabetes mellitus is not clear, they are used in diagnosis and can identify subjects at high risk for the developmentof the disease.
Key words:
insulin-dependent diabetes mellitus, autoimmune disease, autoantibodies, glutamate decarboxylase,tyrosine phosphatase.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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