Autoantibodies in the Pathogenesis and Diagnosis of Insulin-dependent Diabetes Mellitus

Authors: M. Prázný ;  J. Škrha
Authors‘ workplace: III. interní klinika 1. LF UK a VFN, Praha
Published in: Čas. Lék. čes. 1999; : 268-271


Insulin-dependent diabetes mellitus is considered an autoimmune disease. The immune response is targeted onautoantigens of B-cells of the islets of Langerhans. The most important autoantigens are glutamic acid decarboxylase,protein tyrosine phosphatase and insulin. Despite the fact that their role in the pathogenesis of insulin-dependentdiabetes mellitus is not clear, they are used in diagnosis and can identify subjects at high risk for the developmentof the disease.

Key words:
insulin-dependent diabetes mellitus, autoimmune disease, autoantibodies, glutamate decarboxylase,tyrosine phosphatase.

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