The prevalence of type 2 diabetes mellitus in patients with autoimmune thyroiditis in hypothyroid stadium

Authors: Štefan Sotak;  Ivica Lazúrová;  Marek Felšöci;  Božena Nováková;  Hedviga Wagnerová
Authors‘ workplace: I. interná klinika LF UPJŠ a UN L. Pasteura Košice, Slovenská republika
Published in: Vnitř Lék 2018; 64(3): 232-235
Category: Original Contributions


Autoimmune thyroiditis (AIT) and type 2 diabetes mellitus (DM2T) are the two most common endocrinological diseases worldwide. The relationship between T1DM and autoimmune thyreopathies is known and described, but the relationship between thyreopathies and diabetes type 2 is not clarified sufficiently through that studies manifest increasingly the connection between them.

Investigate the prevalence of DM2T in patients with AIT in hypothyroid stadium and compare with common population and investigate a possible association between thyroid and glucose metabolism parameters.

Material and methods:
The group consisted of 100 patients (33 men and 67 women) with AIT without until now documented glucose metabolism disorder, average age 65.63 ± 19.05 years. The control group (CG) consisted of 100 subjects without until now documented thyreopathy and glucose metabolism disorder (37 men and 63 women), average age 63.85 ± 18.98 years. We realised venous blood sampling and determined thyroidal and glycid metabolism parameters.

The study did not confirm higher prevalence of diabetes in patients with AIT [3 (3 %) vs 4 (4 %), p = 1]. There were no statistical significant differences between glycid metabolism parameters in patients with AIT and CG. Also no glycid metabolism parameters correlated to thyroidal parameters.

We did not confirm higher prevalence of DM in patients with AIT.

Key words:
autoimmune thyroiditis – diabetes mellitus type 2


1. Schroner Z, Lazúrová I, Petrovičová J. Autoimmune thyroid diseases in patients with diabetes mellitus. Bratisl Lek Listy 2008; 109(3): 125–129.

2. Hage M, Zantout, M Aznar S Thyroid Disorders and Diabetes Mellitus. J Thyroid Res 2011; 2011: 439463. Dostupné z DOI: <>.

3. Schroner Z, Uličiansky V. Diabetes mellitus a ochorenia štítnej žľazy. Forum Diab 2014; 3(3): 135–141.

4. Ittermann T, Markus MRP, Schipf S et al. Metformin inhibits goitrogenous effects of type 2 diabetes. Eur J Endocrinol 2013; 169(1): 9–15. Dostupné z DOI: <–0101>.

5. Gierach M, Gierach J, Skowrońska A et al. Hashimoto’s thyroiditis and carbohydrate metabolism disorders in patients hospitalised in the Department of Endocrinology and Diabetology of Ludwik Rydygier Collegium Medicum in Bydgoszcz between 2001 and 2010. Endokrynol Pol 2012; 63(1): 14–17.

6. Zamrazil V. Subklinické tyreopatie. Vnitř Lék 2007; 53(7–8): 795–798.

7. Duntas LH, Orgiazzi J, Brabant G. The interface between thyroid and diabetes mellitus. Clin Endocrinol (Oxf) 2011; 75(1): 1–9. Dostupné z DOI: <–2265.2011.04029.x>.

8. McCulloch AJ, Johnston DG, Baylis PH et al. Evidence that thyroid hormones regulate gluconeogenesis from glycerol in man. Clin Endocrinol (Oxf) 1983; 19(1): 67–76.

9. McDaniel HG, Pittman CS, Oh SJ et al. Carbohydrate metabolism in hypothyroid myopathy. Metabolism 1977; 26(8): 867–873.

10. Clausen N, Lins PE, Adamson U et al. Counterregulation of insulin-induced hypoglycaemia in primary hypothyroidism. Acta Endocrinol (Copenh) 1986; 111(4): 516–521.

11. Müller MJ, Seitz HJ. Interrelation between thyroid state and the effect of glucagon on gluconeogenesis in perfused rat livers. Biochem Pharmacol 1987; 36(10): 1623–1627.

12. Stanická S, Vondra K, Pelikánová T et al. Insulin sensitivity and counter-regulatory hormones in hypthyroidism and during thyroid hormone replacement therapy. Clin Chem Lab Med 2005; 43(7): 715–720. Dostupné z DOI: <>.

13. Dimitriadis G, Mitrou P, Lambadiari V et al. Insulin action in adipose tissue and muscle in hypothyroidism. J Clin Endocrinol Metab 2006; 91(12): 4930–4937. Dostupné z DOI: <–0478>.

14. Maratou E, Hadjidakis DJ, Kollias A et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol 2009; 160(5): 785–790. Dostupné z DOI: <–0797>.

15. Dimitriadis G, Parry-Billings M, Bevan S et al. The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats. Eur J Clin Invest 1997; 27(6): 475–483.

16. Rochon C, Tauveron I, Dejax C et al. Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism. Clin Sci 2003; 104(1): 7–15. Dostupné z DOI: <>.

17. Cettour-Rose P, Samec S, Russell AP et al. Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: a link between catch-up growth and later metabolic syndrome. Diabetes 2005; 54(3): 751–756.

18. Johnson AB, Webber J, Mansell P et al. Cardiovascular and metabolic responses to adrenaline infusion in patients with short term hypothyroidism. Clin Endocrinol (Oxf) 1995; 43(6): 747–751.

19. Kapadia KB, Bhatt PA, Shah JS. Association between altered thyroid state and insulin resistance. J Pharmacol Pharmacother 2012; 3(2): 156–160. Dostupné z DOI: <–500X.95517>.

20. Ujwal Upadya B, Suma MN, Srinath KM et al. Effect of Insulin Resistance in Assessing the Clinical Outcome of Clinical and Subclinical Hypothyroid Patients. J Clin Diagn Res 2015; 9(2): OC01–4. Dostupné z DOI: <>.

21. Vyakaranam S, Vanaparthy S, Nori S et al. Study of Insulin Resistance in Subclinical Hypothyroidism. Int J Health Sci Res 2014; 4(9): 147–153.

22. Al-Shoumer KAS, Vasanthy BA, Al-Zaid MM. Effect of treatment of Hyperthyroidism on Glucose Homeostasis, Insulin Secretion, and Markers of Bone Turnover. Endocr Pract 2006; 12(2): 121–130. Dostupné z DOI: <>.

23. Yasmin T, Ghafoor F, Malik T et al. Pattern of thyroid autoimmunity in type 1 and type 2 diabetics. J Coll Physicians Surg Pak 2006; 16(12): 751–754.

24. Tereshschenko IB, Suslina AA. Comparative analysis of the changing pattern of thyroid disease in patients with type 2 diabetes mellitus in the Perm region after 10 years. Ter Ark 2014; 86(10): 15–19.

25. Toulis K, Tsmekmekidou X, Potolidis E et al. Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D. Int J Endocrinol 2015; 2015: 710363. Dostupné z DOI: <>.

Diabetology Endocrinology Internal medicine
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account