Case history acquired haemophilia A


Authors: Z. Čermáková 1;  R. Hrdličková 2;  Š. Blahutová 2;  A. Ligová 3
Authors‘ workplace: Lékařská fakulta OU Ostrava, děkan doc. MU Dr. Jaroslav Horáček, CSc. 1;  Krevní centrum FN Ostrava, přednostka prim. MU Dr. Zuzana Čermáková, Ph. D. 2;  Ústav klinické hematologie Lékařské fakulty OU a FN Ostrava, přednosta prim. MU Dr. Jaromír Gumulec 3
Published in: Vnitř Lék 2013; 59(4): 313-316
Category: Case Reports

Overview

Acquired haemophilia A is a rare form of acquired coagulopathy caused by autoantibodies against coagulation factor VIII. It is characterized by major bleeding complications often life– threatening. An estimated incidence is about 1– 2 cases per million inhabitants per year. The authors report case history of acquired haemophilia in 85 year old woman. Bleeding complications were well controled by bypassing agents. Inhibitor eradication was successful after the use of second line agent rituximab.

Key words:
acquired haemophilia A –  factor VIII inhibitor –  rituximab


Sources

1. Hay CR, Brown S, Collins PW et al. The diagnosis and management of factor VIII and IX inhibitors: a guidline from the United Kingdom Haemophilia Centre Doctors’ Organization. Br J Haematol 2006; 133: 591– 605.

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3. Sborov DW, Rodgers GM. Acquired hemophilia A: a curent review of autoantibody disease. Clin Adv Hematol Oncol 2012; 10: 19– 27.

4. Holme PA, Brosstad F, Tjønnfjord GE. Acquired haemophilia: management of bleeds and immune therapy to eradicate autoantibodies. Haemophilia 2005; 11: 510– 515.

5. Collins P, Baudo F, Huth- Kuhne A et al. Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Research Notes 2010; 3: 161.

6. Smejkal P, Buliková A, Chlupová G et al. Získaná hemofilie A. Vnitř Lék 2012; 58: 571– 578.

7. Collins PW, Hirsch S, Baglin TP et al. Acquired hemophilia A in the United Kingdom: 2‑year national surveillance study by the United Kingdom Haemophilia Centre Doctors’ Organization. Blood 2007; 109: 1870– 1877.

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Labels
Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

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2013 Issue 4

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