Langerhans cell histiocytosis – cutaneous aspects of the disease


Authors: V. Vašků
Authors‘ workplace: I. dermatovenerologická klinika Lékařské fakulty MU a FN u sv. Anny Brno, přednosta doc. MUDr. Vladimír Vašků, CSc.
Published in: Vnitř Lék 2010; 56(Supplementum 2): 91-93
Category: Langerhans cell histiocytosis and some other Hematology rare diseases

Overview

There is discussed nature of Langerhans cell histiocytosis – reactive versus neoplastic. It represents wide clinical spectrum with localised or disseminated types of the disease. Skin lesions are very common and they could be the first symptoms. Usually involved is the scalp and trunk area. The involvement of nails and mucous membranes is possible. From treatment modalities, PUVA (photochemotherapy) is very important and it’s best mode is systemic admission of psoralen with subsequent irradiation by defined part of UVA range. It can be considered as the first choice treatment for skin lesions.

Key words:
Langerhans cell histiocytosis – cutaneous lesions – treatment


Sources

1. Braun-Falco O, Plewig G, Wolff HH. Dermatológia a venerológia. Prvé slovenské a české vydanie. Martin: Osveta 2001: 1321–1327.

2. Bolognia JL, Jorizzo JL, Rapini RP. Dermatology. 2nd ed. Philadelphia: Mosby Elsevier 2008: 1395–1400.

3. Wolff K, Goldsmith LA, Katz SI et al. Fitzpatrick’s dermatology in general medicine. 7th ed. New York: McGraw Hill 2008: 1414–1420.

Labels
Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

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