Langerhans cell histiocytosis – cutaneous aspects of the disease

Authors: V. Vašků
Authors‘ workplace: I. dermatovenerologická klinika Lékařské fakulty MU a FN u sv. Anny Brno, přednosta doc. MUDr. Vladimír Vašků, CSc.
Published in: Vnitř Lék 2010; 56(Supplementum 2): 91-93
Category: Langerhans cell histiocytosis and some other Hematology rare diseases


There is discussed nature of Langerhans cell histiocytosis – reactive versus neoplastic. It represents wide clinical spectrum with localised or disseminated types of the disease. Skin lesions are very common and they could be the first symptoms. Usually involved is the scalp and trunk area. The involvement of nails and mucous membranes is possible. From treatment modalities, PUVA (photochemotherapy) is very important and it’s best mode is systemic admission of psoralen with subsequent irradiation by defined part of UVA range. It can be considered as the first choice treatment for skin lesions.

Key words:
Langerhans cell histiocytosis – cutaneous lesions – treatment


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Diabetology Endocrinology Internal medicine

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